Evidence map›Paper›PMID 39930165›Full record

ReviewAdvances in experimental medicine and biology2025

Macrophages and Age-Related Macular Degeneration.

Evangeline Foster, Amanda-Jayne Carr

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Evangeline FosterUCL Institute of Ophthalmology, London, UK. evangeline.foster@ucl.ac.uk.
Amanda-Jayne CarrUCL Institute of Ophthalmology, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is characterised by the dysfunction of the retinal pigment epithelium (RPE), deposition of drusen and degeneration of the overlying photoreceptors, leading to the loss of central vision. AMD is a complex and multifactorial disease, with the greatest risk factor being age. As we age, changes occur to our immune system, a phenomenon known as inflammageing. There is mounting evidence indicating a role for the immune system in the development, progression, pathology and potentially, treatment of AMD. However, the specific contribution played by immune cells remains unclear. This chapter discusses evidence implicating a role for the circulating macrophages in AMD.

Indexed as

MacrophagesMacular DegenerationAgingAnimalsHumansRetinal Pigment EpitheliumAge-related macular degeneration (AMD)AngiogenesisChoroid neovascularisationComplement factor HComplement systemDrusenInflammageingM1M2MacrophagesPolarisationRetinal pigment epithelium

Identifiers

PMID39930165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.