Observational studySurgical endoscopy2025
Treatment of Boerhaave syndrome: experience from a tertiary center.
Observational study in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Boerhaave Syndrome With Concomitant Duodenal Perforation: A Rare Case Complicated by Mediastinitis and Empyema.Cureus · 2026Article
- Negative Contrast Esophagography Does Not Exclude Dehiscence After Boerhaave Repair: Complementary Low-Insufflation Carbon Dioxide Endoscopy.Diagnostics (Basel, Switzerland) · 2026Article
- Severity-guided management of esophageal perforation: a retrospective cohort study supporting a pragmatic treatment algorithm.World journal of emergency surgery : WJES · 2026Article
- Case Report: Two-stage surgical management of spontaneous oesophageal rupture with extensive necrosis.Frontiers in medicine · 2026Article
- Laparoscopic Management of Boerhaave Syndrome: Case Series and Narrative Review.Life (Basel, Switzerland) · 2025Review
- Multimodal therapeutic options for esophageal perforations-a single-center experience.Frontiers in surgery · 2025Article
- Management of boerhaave's syndrome in the intensive care unit.International journal of critical illness and injury scienceReview
- Spontaneous Pneumomediastinum Associated with Semaglutide Therapy: A Case Report.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoerhaave syndrome is a rare, life-threatening condition, characterized by spontaneous esophageal rupture. This study aims to share our 13-year experience in managing Boerhaave syndrome.
methodsA retrospective, observational study was conducted of consecutive patients with Boerhaave syndrome who presented at our tertiary referral center, between 2011 and 2023. Patients were categorized by time to diagnosis, to assess the impact of diagnostic delay.
resultsAmong 21 patients, 13 (62%) were diagnosed early (< 24 h) and 8 (38%) late (> 24 h). In the early-diagnosed group (n = 13), 6 patients (46%) received primary intervention with stent placement in combination with surgical drainage (5 with mediastinal and pleural drainage and 1 with only pleural drainage), while 5 patients (38%) were initially treated with only a stent. One patient (8%) underwent surgical pleural drainage alone and one (8%) underwent an esophagectomy. Among the 8 late-diagnosed patients, 4 (50%) were primarily treated with both stent placement and surgical drainage (2 with mediastinal drainage, 1 with pleural drainage and 1 with both), 3 (38%) with only stent placement, and one (13%) was managed conservatively. Additional interventions were required in 14 patients (67%). Additional surgical drainage was performed in 5 of 8 patients who had initially been treated with stent only (63%) and in 2 of 10 patients who had initially received both stent and surgical drainage (20%). Stent complications occurred in 7 patients (37%), including leakage (16%), migration (16%), and bleeding (5%). The median hospital stay was 32 days (IQR 15-37) and the overall 90-day mortality was 14%. Mortality was significantly higher in late-diagnosed patients (n = 3, 38%) compared to those early diagnosed (n = 0, 0%) (p = 0.042), with all 3 deceased patients either refusing or being unfit for treatment.
conclusionBased on this study, we recommend prioritizing closure of the defect combined with drainage, while considering individual patient factors, including advanced age.
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