SynthesisNature genetics2025
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Benefits and Harms of Screening for Prostate Cancer in Adults Aged 18 Years and Older: A Systematic Review.Current oncology (Toronto, Ont.) · 2026Pooled it
- Integrating multi-omics data for next-generation cancer research and precision medicine.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Germline polygenic score for prostate cancer aggressiveness.medRxiv : the preprint server for health sciences · 2026Article
- Prostate cancer germline variants with therapeutic implications.Trends in molecular medicine · 2026Review
- Clinical translation of polygenic scores for prostate cancer screening.Nature reviews. Urology · 2026Review
- Prostate cancer risk-associated single-nucleotide polymorphisms impact the conformational dynamics of prostate-specific antigen.BMC biology · 2025Article
- Performance of GPT-4 for automated prostate biopsy decision-making based on mpMRI: a multi-center evidence study.Military Medical Research · 2025Article
- The accuracy of polygenic score models for BMI and Type II diabetes in the Native Hawaiian population.Communications biology · 2025Article
- Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer.HGG advances · 2024Article
Corrections and comments
- Update of
Authors and funding
49 authors.
Thomas J Hoffmann *Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6893-4449
Rebecca E Graff *Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0316-8303
Ravi K MadduriData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.ORCID 0000-0003-2130-2887
Alex A RodriguezData Science and Learning Division, Argonne National Laboratory, Argonne, IL, USA.
Clinton L CarioDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Karen FengDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5763-300X
Yu JiangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2914-8300
Anqi WangCenter for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0552-4642
Robert J KleinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3539-5391
Brandon L PierceDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7829-952X
Scott EggenerComprehensive Cancer Center, University of Chicago, Chicago, IL, USA.
Lin TongDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
William BlotDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jirong LongDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Louisa B GossPublic Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0005-2936-2405
Burcu F DarstPublic Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-6205-4632
Timothy RebbeckDana Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-4799-1900
Joseph LachanceSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-4650-3741
Caroline AndrewsDana Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Akindele O AdebiyiDepartment of Community Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0003-1869-7910
Ben Adusei37 Military Hospital, Accra, Ghana.
Oseremen I Aisuodionoe-ShadrachCollege of Health Sciences, University of Abuja, Abuja, Nigeria.
Pedro W FernandezFaculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-8728-9032
Mohamed JallohHospital General Idrissa Pouye, Dakar, Senegal.ORCID 0000-0002-2190-328X
Rohini JanivaraSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-0634-2357
Wenlong C ChenStrengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-3248-4906
James E MensahKorle-Bu Teaching Hospital and University of Ghana Medical School, Accra, Ghana.ORCID 0000-0003-4133-1722
Ilir AgalliuDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0002-6248-5790
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
John P ShelleyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Kerry SchafferDivision of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6538-9705
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-4440-3368
Shengchao A LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Phyllis J GoodmanSWOG Statistics and Data Management Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Cathee TillSWOG Statistics and Data Management Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ian ThompsonCHRISTUS Santa Rosa Medical Center Hospital, San Antonio, TX, USA.
Hans LiljaDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dilrini K RanatungaKaiser Permanente Research Bank, Oakland, CA, USA.
Joseph PrestiDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-5599-8387
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-2324-3393
Jonathan D MosleyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-6421-2887
David V ContiCenter for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2941-7833
Christopher A HaimanCenter for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Amy C JusticeVeterans Administration Connecticut Healthcare System, West Haven, CT, USA.ORCID 0000-0003-0139-5502
Linda KachuriDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. lkachuri@stanford.edu.ORCID 0000-0002-3226-4727
John S WitteDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. jswitte@stanford.edu.ORCID 0000-0003-0146-1434
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MTechnology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MVIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014599NCI NIH HHS P50 CA097186NCI NIH HHS R00 CA246063NCI NIH HHS R00 CA246076NCI NIH HHS R01 CA175491NCI NIH HHS R01 CA241410NCI NIH HHS R01 CA244948NCI NIH HHS U01 CA184374NCI NIH HHS U01 CA224255NCI NIH HHS U01 CA261339NCI NIH HHS U01 CA266535NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NIA NIH HHS RC2 AG036607NIEHS NIH HHS P30 ES027792NIGMS NIH HHS R01 GM130791NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS S10 OD026880NIH HHS S10 OD030463NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196
Abstract
We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (P ≤ 5 × 10
Indexed as
Genome-Wide Association StudyProstate-Specific AntigenProstatic NeoplasmsAgedAsian PeopleBlack PeopleCohort StudiesGenetic Predisposition to DiseaseHispanic or LatinoHumansMaleMiddle AgedMultifactorial InheritancePolymorphism, Single NucleotideWhite PeopleProstate-Specific Antigen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.