Evidence map›Paper›PMID 39930060›Full record

ArticleArchives of toxicology2025

Evaluation of the toxicity of combustion smokes at the air-liquid interface: a comparison between two lung cell models and two exposure methods.

A Ashrin, E Anna, E Peyret, G Barbier, Maxime Floreani, C Pointart, D Medus, G Fayet, P Rotureau, T Loret and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A AshrinExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
E AnnaExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
E PeyretExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
G BarbierExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
Maxime FloreaniExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
C PointartEtienne LACROIX Group, Route de Gaudies, 09270, Mazeres, France.
D MedusEtienne LACROIX Group, Route de Gaudies, 09270, Mazeres, France.
G FayetChemical and Electrochemical Reactions Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
P RotureauDepartment of Strategy, Scientific Policy and Communication, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France.
T LoretExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France. thomas.loret@ineris.fr.ORCID 0000-0001-9171-9819
G LacroixExperimental Toxicology and Modelling Unit, French National Institute for Industrial Environment and Risks (Ineris), Parc Alata, 60550, Verneuil-en-Halatte, France. ghislaine.lacroix@ineris.fr.

Funding

Direction Générale de l'Armement 2020-92-0907
6 · The paper itself

Abstract

In vitro tests at the air-liquid interface (ALI) represent valuable alternatives to animal experiments to assess the acute toxicity of inhalable compounds. However, these methods still need to be characterized for the toxicity evaluation of complex mixtures such as combustion smokes. In this study, Alveolar type I or Alveolar type 2 cells in co-culture with macrophages were investigated as models for evaluating the acute toxicity of complex mixtures at the air-liquid interface. In that purpose, smokes/obscurants were generated from pyrotechnic devices of known toxic potentials in a 1.3 m

Indexed as

Air PollutionLungSmokeA549 CellsCell LineEnvironmental ExposureExplosive AgentsHumansLipopolysaccharidesReactive Oxygen SpeciesExplosive AgentsLipopolysaccharidesReactive Oxygen SpeciesSmokeAir–liquid interfaceIn vitroLung toxicityMixturesSmokes/obscurants

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.