ArticleScientific reports2025
Hemodynamic effects of stenosis with varying severity in different segments of the carotid artery using computational fluid dynamics.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The influence of stenosis severity and geometric orientation on atherosclerotic progression: A fluid-structure interaction study in the carotid artery.Physical and engineering sciences in medicine · 2026Article
- Plaque-Level Machine Learning Prediction of Intraplaque Hemorrhage in Carotid Arteries Using Computed Tomography Angiography.Clinical neuroradiology · 2026Article
- Pathophysiology of Atherosclerotic Carotid Disease.Seminars in neurology · 2026Review
- Patient-Specific Fluid-Structure Interaction Simulations Suggest Wall-Shear-Stress-Related Biomarkers in Type B Dissection Associated with Marfan Syndrome.Annals of biomedical engineering · 2026Article
- Haemodynamic and biomechanical biomarker analysis of carotid fibromuscular dysplasia via fluid-structure interaction.Biomechanics and modeling in mechanobiology · 2026Article
- A multi-fractal vascular tree model for characterizing blood flow in cardiovascular system.Scientific reports · 2026Article
- Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors.Translational stroke research · 2026Observational
- Automated Detection of Carotid Artery Stenosis Using a Sensitive Accelerometer Wearable Sensor and Interpretable Machine Learning.Biosensors · 2026Article
- Physics-informed graph neural networks for real-time prediction of wall shear stress in stenotic coronary arteries.Scientific reports · 2026Article
- Microfluidic Chamber Design for Organ-on-a-Chip: A Computational Fluid Dynamics Study of Pillar Geometry and Pulsatile Perfusion.Biosensors · 2026Article
- Fluid-Structure Interaction Analysis of Hyoid Bone-Induced Compression on Carotid Artery Hemodynamics.Biomedical engineering and computational biology · 2026Article
- Article
- Comparative Analysis of Open-Source Finite Element Method Solvers for Computational Fluid Dynamics Performance in a Carotid Artery Model.Journal of biomechanical engineering · 2026Article
- Anisotropic hyperelastic properties of porcine pericardium under equibiaxial loading: implications for aortic valve design.Frontiers in bioengineering and biotechnology · 2026Article
- Risk stratification in intermediate asymptomatic carotid artery disease: a multi-modal approach combining local flow dynamics and systemic clinical profiles.Frontiers in surgery · 2026Article
- The vertebro-subclavian artery angle modulates hemodynamic mechanisms of atherosclerosis in vertebral artery origin: a combined clinical and computational fluid dynamics study.Frontiers in bioengineering and biotechnology · 2026Article
- Phase-specific turbulence index derived from vector flow imaging for identifying intraplaque neovascularization in carotid plaques.Frontiers in cardiovascular medicine · 2026Article
- Hemodynamics in carotid artery stenosis.International angiology : a journal of the International Union of Angiology · 2025Review
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Authors and funding
9 authors.
Funding
Abstract
Carotid atherosclerosis is a leading cause of ischemic stroke. As a result of atherosclerotic plaque formation, the carotid artery lumen narrows, leading to significant hemodynamic alterations. These changes can further contribute to the development of subsequent lesions. In this study, we built 54 idealized carotid artery stenosis (CAS) models by using a single healthy carotid artery to simulate six different degrees of stenosis at nine various locations. Computational fluid dynamics (CFD) was applied to analyze blood flow changes, focusing on three key hemodynamic indicators: wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT). Numerical simulations and model validations were conducted to ensure the correctness and validity of the results. The results show that increasing stenosis severity leads to higher WSS values at the site of stenosis, which may facilitate plaque rupture, while OSI and RRT decrease at the stenosis site. In the external carotid artery (ECA) and internal carotid artery (ICA), increasing stenosis severity results in a reduction in WSS at bifurcation sites, promoting plaque formation. These findings offer new insights into the hemodynamic changes associated with carotid artery stenosis and provide a solid foundation for future research and clinical applications.
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