Evidence map›Paper›PMID 39929877›Full record

Trial reportScientific reports2025

Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery.

L I Sgaramella, A Pasculli, M Moschetta, F Puntillo, P Dicillo, L Clemente, M Maruccia, M G Mastropasqua, M Piombino, N Resta and 8 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

L I SgaramellaDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0002-6087-4119
A PasculliDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0003-2276-2383
M MoschettaBreast Care Unit, Policlinico of Bari, University of Medical School of Bari, P.zza G. Cesare 11, 70124, Bari, Italy.ORCID 0000-0003-1771-8337
F PuntilloBreast Care Unit, Policlinico of Bari, University of Medical School of Bari, P.zza G. Cesare 11, 70124, Bari, Italy.ORCID 0000-0001-7274-6467
P DicilloRehabilitation Service, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
L ClementeDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.
M MarucciaDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0002-2122-2732
M G MastropasquaDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0002-8306-0839
M PiombinoBreast Care Unit, Policlinico of Bari, University of Medical School of Bari, P.zza G. Cesare 11, 70124, Bari, Italy.ORCID 0009-0004-6020-7852
N RestaDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0001-8640-5532
G RubiniBreast Care Unit, Policlinico of Bari, University of Medical School of Bari, P.zza G. Cesare 11, 70124, Bari, Italy.ORCID 0000-0003-1972-3308
F P PreteDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0003-0426-8752
G SerioDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0001-9021-4560
L S StucciBreast Care Unit, Policlinico of Bari, University of Medical School of Bari, P.zza G. Cesare 11, 70124, Bari, Italy.ORCID 0000-0003-2063-1435
G GiudiceDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0003-3883-8901
M TestiniDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy.ORCID 0000-0002-9297-4894
Angela GurradoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePreJ), Aldo Moro University, Bari, Italy. angela.gurrado@uniba.it.ORCID 0000-0002-2009-5831
BCU PoliBa Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of study is to analyze Bromelain' effects on the most common early complications after BCS (oedema and seroma). From January 2021 to December 2023 a double-blind randomized placebo-controlled trial was performed on 114 candidates for BCS at our Academic Unit. Group A received a supplement of Casperome™-Boswellia Phytosome

Indexed as

Breast NeoplasmsBromelainsPostoperative ComplicationsThioctic AcidAdultDouble-Blind MethodEdemaFemaleHumansMiddle AgedSeromaTreatment OutcomeBromelainsThioctic AcidBreast cancerBreast conserving surgeryBreast oedemaBreast seromaEarly complicationsPost-surgical painSurgical outcomes

Identifiers

PMID39929877
PMCPMC11811023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.