Evidence map›Paper›PMID 39929862›Full record

ArticleScientific reports2025

Predictive value and mediating effect analysis of the AHR-ARNT-CYP1A1 axis for missed abortion related to polycyclic aromatic hydrocarbons exposure.

Jiuru Cao, Mei Han, Fuxing Li, Jiayu Zhang, Jingru Ji, Junni Wei

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Jiuru CaoDepartment of Epidemiology, School of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Mei HanDepartment of Epidemiology, School of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Fuxing LiDepartment of Epidemiology, School of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Jiayu ZhangDepartment of Epidemiology, School of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Jingru JiDepartment of Obstetrics and Gynecology, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Junni WeiDepartment of Epidemiology, School of Public Health, Shanxi Medical University, No. 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. junni.wei@sxmu.edu.cn.

Funding

Shanxi Provincial Basic Research Project of China 201901D111206Shanxi Provincial Health Commission Scientific Research Project of China 2020086
6 · The paper itself

Abstract

This study aimed to determine the predictive value of aryl hydrocarbon receptor (AHR) signaling pathway genes, and to detect the mediating effect of AHR that may mediate the influence of polycyclic aromatic hydrocarbons (PAHs) on missed abortion. The present study was conducted using a 1:2 matched case-control study, a total of 94 cases of women with missed abortion and 188 matched women controls with normal pregnancy but voluntarily abortion were included. The receiver operating characteristic curve (ROC) and the area under the ROC curve (AUC) were used to evaluate the predictive value of AHR signaling pathway genes for missed abortion. The mediating role of AHR within the effect pathway between PAHs exposure and missed abortion was performed using the mediation package of the R language. The results showed that the level of PAH-DNA adducts in the case group (487.61 ± 6.29) pg/ml was higher than that in the control group (446.86 ± 5.95) pg/ml (P < 0.001). There were significant differences in the expression levels of AHR, aryl hydrocarbon receptor nuclear translocator (ARNT), aryl hydrocarbon receptor repressor (AHRR), cytochrome P450 enzymes 1A1 (CYP1A1) and glutathione S-transferase P1 (GSTP1) genes between the case group and the control group (P < 0.01). After adjusting for covariates, high exposure of PAH-DNA adducts levels increased AHR and CYP1A1 expression. The 5-fold cross-validation results revealed that the mean value of the area under the ROC curve (AUC) of AHR-ARNT-CYP1A1 axis was 0.931 (95%CI: 0.858 ~ 0.999), which had good predictive performance in assessing the risk of prevalence of missed abortion. AHR gene might play a partial mediating effect in the association between PAHs exposure and missed abortion, and the percentage of mediating effect was 36.56%.

Indexed as

Abortion, MissedAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsCytochrome P-450 CYP1A1Polycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonAdultCase-Control StudiesDNA AdductsFemaleHumansPregnancyROC CurveSignal TransductionAHR protein, humanARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsCYP1A1 protein, humanCytochrome P-450 CYP1A1DNA AdductsPolycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonAHR signaling pathwayMediating effectMissed abortionPAH-DNA adductsPrediction model

Identifiers

PMID39929862
PMCPMC11810996

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