Evidence map›Paper›PMID 39929825›Full record

ArticleNature communications2025

A neuronal code for object representation and memory in the human amygdala and hippocampus.

Runnan Cao, Peter Brunner, Puneeth N Chakravarthula, Krista L Wahlstrom, Cory Inman, Elliot H Smith, Xin Li, Adam N Mamelak, Nicholas J Brandmeir, Ueli Rutishauser and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Multidimensional Feature Tuning in Category Selective Areas of Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Runnan CaoDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA. r.cao@wustl.edu.ORCID http://orcid.org/0000-0001-5827-9903
Peter BrunnerDepartment of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA.
Puneeth N ChakravarthulaDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Krista L WahlstromDepartment of Psychology, University of Utah, Salt Lake City, UT, USA.
Cory InmanDepartment of Psychology, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-2928-6252
Elliot H SmithDepartment of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Xin LiDepartment of Computer Science, University at Albany, Albany, NY, USA.ORCID http://orcid.org/0000-0003-2067-2763
Adam N MamelakDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4245-6431
Nicholas J BrandmeirDepartment of Neurosurgery, West Virginia University, Morgantown, WV, USA.
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jon T WillieDepartment of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. jontwillie@wustl.edu.ORCID http://orcid.org/0000-0001-9565-4338
Shuo WangDepartment of Radiology, Washington University in St. Louis, St. Louis, MO, USA. shuowang@wustl.edu.ORCID http://orcid.org/0000-0003-2562-0225

Funding

Training and DisseminationP41EB018783 · NIBIB · WADSWORTH CENTER · PI Yi Chen · 2014 to 2026
$15.4M
The Role of Place and Grid Cells in Human Spatial Navigation and MemoryR01MH104606 · NIMH · UNIVERSITY OF CHICAGO · PI Joshua Jacobs · 2015 to 2026
$6.5M
An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in HumansU01NS128612 · NINDS · MAYO CLINIC ROCHESTER · PI Peter Brunner, Kai Miller · 2022 to 2026
$4.5M
BCI2000: Software Resource for Adaptive Neurotechnology ResearchU24NS109103 · NINDS · WASHINGTON UNIVERSITY · PI BRUNNER, PETER · 2019 to 2024
$2.8M
Model-Based Investigation of Aberrant Neural Face Representation in AutismR01MH129426 · NIMH · WASHINGTON UNIVERSITY · PI Shuo Wang · 2022 to 2026
$1.9M
Mechanisms of Amygdala-Mediated Memory Enhancement in HumansR01MH120194 · NIMH · WASHINGTON UNIVERSITY · PI WILLIE, JON TIMOTHY · 2020 to 2024
$1.8M
BCI2000+: A Software Platform for Adaptive NeurotechnologiesR01EB026439 · NIBIB · WASHINGTON UNIVERSITY · PI BRUNNER, PETER · 2018 to 2022
$1.5M
Dynamics and Causal Functions of Large-Scale Cortical and Subcortical NetworksU01NS108916 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 2018 to 2019
$1.4M
Non-invasive vagus nerve stimulation to mitigate subarachnoid hemorrhage induced inflammationR21NS128307 · NINDS · WASHINGTON UNIVERSITY · PI BRUNNER, PETER, LEUTHARDT, ERIC CLAUDE · 2023 to 2024
$428k
Delineating the neural computational network for object recognitionK99EY036650 · NEI · WASHINGTON UNIVERSITY · PI CAO, RUNNAN · 2024 to 2025
$228k
NEI NIH HHS K99 EY036650NIBIB NIH HHS P41 EB018783NIBIB NIH HHS R01 EB026439NIMH NIH HHS R01 MH104606NIMH NIH HHS R01 MH120194NIMH NIH HHS R01 MH129426NINDS NIH HHS R21 NS128307NINDS NIH HHS U01 NS108916NINDS NIH HHS U01 NS128612NINDS NIH HHS U24 NS109103
6 · The paper itself

Abstract

How the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neurons in the human amygdala and hippocampus across four experiments. We employed both passive-viewing and recognition memory tasks involving a diverse range of naturalistic object stimuli. Our findings reveal a region-based feature code for general objects, where neurons exhibit receptive fields in the high-level visual feature space. This code can be validated by independent new stimuli and replicated across all experiments, including fixation-based analyses with large natural scenes. This region code explains the long-standing visual category selectivity, preferentially enhances memory of encoded stimuli, predicts memory performance, encodes image memorability, and exhibits intricate interplay with memory contexts. Together, region-based feature coding provides an important mechanism for visual object processing in the human brain.

Indexed as

AmygdalaHippocampusMemoryNeuronsVisual PerceptionAdultFemaleHumansMalePattern Recognition, VisualPhotic StimulationRecognition, PsychologyYoung Adult

Identifiers

PMID39929825
PMCPMC11811184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.