ArticleAnnals of Saudi medicine
Incidence, outcomes, and mortality risk factors of acute kidney injury in critically ill children: a tertiary care center study in Saudi Arabia.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Acute kidney injury in critically ill children: Incidence, severity, and clinical outcomes from a quaternary pediatric intensive care unit in an upper-middle-income country.Pediatric nephrology (Berlin, Germany) · 2026Article
- Acute Kidney Injury in Critically Ill Children: A Retrospective Single-Center Study.Children (Basel, Switzerland) · 2026Article
- Pediatric Dialysis: From Acute Kidney Injury to Chronic Renal Replacement Therapies: Challenges and Perspectives in Resource-Limited Countries.Diseases (Basel, Switzerland) · 2026Review
- Clinical Characteristics, Microbiological Profile, and Mortality Predictors in Pediatric Community-Acquired Sepsis: A Single-Center Study.Turkish archives of pediatrics · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is a critical concern in pediatric intensive care units (PICUs) due to its high mortality rate.
objectivesInvestigate AKI incidence, outcomes, and mortality-related risk factors among critically ill children.
designRetrospective cohort.
settingA PICU. PATIENTS AND
methodsThe study included children (aged 4 weeks to 14 years) who were admitted to the PICU from (2016 to 2019) and developed AKI at King Faisal Specialist Hopsital and Research Centre. MAIN OUTCOMES MEASURES: AKI incidence, outcomes, and mortality-related risk factors. SAMPLE SIZE: 111 records of patients with AKI.
resultsOf 969 PICU admissions, 111 cases developed AKI and were entered in the analysis, with an incidence rate of (11.5%). The median age was 43 months [interquartile range (IQR): 16-120], with hematology/oncology conditions being the most prevalent underlying diseases (56.8%). Septic shock and nephrotoxin medications were the leading causes of AKI, accounting for (46.8%) and (45.0%), respectively. Regarding AKI severity, (37.8%) were classified as stage 1, (25.2%) as stage 2, and (37.0%) as stage 3 AKI. As for PICU interventions, the highest was inotropic support (63.1%), followed by mechanical ventilation (56.8%) and renal replacement therapy (23.4%). The PICU mortality rate was (38.7%) (43/111), with no significant association between AKI stage and mortality. However, the multivariable analysis identified bone marrow transplant (BMT) (
conclusionThese findings underscore the importance of early recognition and tailored management of AKI in PICU settings. Despite advancements in critical care, AKI remains a significant challenge, contributing to prolonged hospitalization, mortality, and increased health-care resource utilization. Therefore, more investigation is warranted. LIMITATIONS: Retrospective study single-center nature.
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