Evidence map›Paper›PMID 39929609›Full record

ReviewClinical & experimental ophthalmology2025

Progress in Translating Glaucoma Genetics Into the Clinic: A Review.

Antonia Kolovos, Giorgina Maxwell, Emmanuelle Souzeau, Jamie E Craig

Abstract readReview
In one paragraph

Review in Clinical & experimental ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Antonia KolovosFlinders Health and Medical Research Institution, Flinders University, Adelaide, Australia.ORCID 0000-0001-6618-0137
Giorgina MaxwellFlinders Health and Medical Research Institution, Flinders University, Adelaide, Australia.ORCID 0000-0002-4837-2204
Emmanuelle SouzeauFlinders Health and Medical Research Institution, Flinders University, Adelaide, Australia.ORCID 0000-0002-2015-6577
Jamie E CraigFlinders Health and Medical Research Institution, Flinders University, Adelaide, Australia.ORCID 0000-0001-9955-9696

Funding

National Health and Medical Research Council Investigator Grant 2016545National Health and Medical Research Council Investigator Grant 2026787
6 · The paper itself

Abstract

Precision medicine is paving the way for personalised risk assessment, and its translation into glaucoma clinics holds potential to change current management paradigms. Our understanding of glaucoma's genetic architecture has expanded in recent years, recognising both monogenic and polygenic contributions. Genetic testing within glaucoma populations can provide additional information for clinicians to support decision-making. Here, we review the evidence base for genetic variants strongly associated with glaucoma and outline a vision for translating these learnings into the clinic. Integrating clinical and genetic information will provide clinicians and patients with the strongest evidence to deliver personalised glaucoma management.

Indexed as

Genetic Predisposition to DiseaseGlaucomaPrecision MedicineTranslational Research, BiomedicalGenetic TestingHumansIntraocular Pressureglaucomamendelianmonogenicpolygenic risk scorespolygenic scores

Identifiers

PMID39929609
PMCPMC11962708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.