ArticleOphthalmology2025
Factors Associated with Vision Outcomes in Microbial Keratitis: A Multisite Prospective Cohort Study.
Article in Ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04420962 (Quantifying Microbial Keratitis to Predict Outcomes), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantifying Microbial Keratitis to Predict Outcomes
Who cites it
7 citing papers in PubMed.
- Association of Deep Learning Imaging Algorithm Measures of Microbial Keratitis With Vision Outcomes.Cornea · 2026Article
- Real-World Management and Patterns of Antibiotic Use in Patients with Keratitis and Ocular Surface Injuries: A Nationwide Survey Study in Spain.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Trends in pathogens causing microbial keratitis in studies conducted in Mexico: a 38-year literature review.International ophthalmology · 2026Review
- Deep Learning-Based Classification of Slit-Lamp Photograph Quality in Microbial Keratitis.Ophthalmology science · 2026Article
- A multicenter retrospective study of non-traumatic corneal perforation: etiology, disease course, clinical manifestations, and treatment strategies.International journal of ophthalmology · 2026Article
- Anatomic Biomarkers Predict Poor Presenting Visual Acuity in Infectious Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
purposeTo investigate factors associated with 90-day vision in patients with microbial keratitis (MK).
designMulticenter prospective cohort study recruited patients with MK from the United States and India from July 23, 2020, through May 1, 2024, and followed them for 90 days.
participantsIndividuals ≥ 15 years of age with MK of > 2 mm
methodsData on sociodemographics, history, symptoms, clinical measures, and best-corrected visual acuity (BCVA) (as logarithm of the minimum angle of resolution [logMAR] units) at initial and 90-day visits were gathered, with BCVA carried forward for those healed before 90 days. Features were summarized overall and by site. Site-stratified multivariable linear regression models were investigated for associations with 90-day BCVA.
main outcome measuresNinety-day logMAR BCVA.
resultsOf 479 participants analyzed, after exclusions (n = 31) and participants without a 90-day BCVA (n = 52), participants had an average 90-day BCVA of 1.36 ± 1.40 logMAR in the United States (US) and 0.70 ± 0.99 logMAR in India (P < 0.0001). For the US, worse 90-day BCVA was associated with worse presenting BCVA (β = 0.05-logMAR per 0.1-logMAR unit increase in presenting BCVA; P < 0.0001), longer time until presentation (β = 0.01 per day; P < 0.0001), no contact lens use (β = 0.46; P = 0.0131), and larger stromal infiltrate area (bacterial: β = 0.02 per 1-mm
conclusionsInitial vision, longer time until presentation, and larger infiltrate size conferred risk for worse 90-day BCVA, whereas other factors were unique. Systems to mitigate care delays and to support access care are needed would support clinicians and improve vision outcomes. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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