Evidence map›Paper›PMID 39929281›Full record

ArticleToxicology and applied pharmacology2025

ADAMTS13 attenuates renal fibrosis by suppressing thrombospondin 1 mediated TGF-β1/Smad3 activation.

Jie Guo, Suhan Zhou, Honghong Wang, Xingyu Qiu, Fang Dong, Shan Jiang, Nan Xu, Yu Cui, Ruisheng Liu, Pengyun Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jie GuoKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Suhan ZhouKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Honghong WangKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Xingyu QiuKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Fang DongKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Shan JiangKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Nan XuKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China; Department of Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Yu CuiKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Ruisheng LiuDepartment of Molecular Pharmacology & Physiology, University of South Florida College of Medicine, Tampa, FL, USA.
Pengyun LiKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China. Electronic address: lpyun@swmu.edu.cn.
Zufu MaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: mazufu@tjh.tjmu.edu.cn.
Liang ZhaoDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, and Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou, China. Electronic address: liang.zhao@zju.edu.cn.
En Yin LaiKidney Disease Center of the First Affiliated Hospital, and Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: laienyin@zju.edu.cn.

Funding

Tubuloglomerular feedback response in AKI to CKD transitionR01DK134028 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2022 to 2025
$2.6M
Protection of donor kidney and transplanted graft function by modulating Na/K ATPase activityR01DK138092 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI WEI CHEN, RUISHENG LIU · 2024 to 2026
$2.0M
Treatment of lupus nephritis with nanoparticles that selectively target kidney glomeruliR01DK134000 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI RUISHENG LIU, Shyam S Mohapatra · 2023 to 2026
$1.9M
NIDDK NIH HHS R01 DK134000NIDDK NIH HHS R01 DK134028NIDDK NIH HHS R01 DK138092
6 · The paper itself

Abstract

Renal fibrosis is a common pathologic pathway for the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD). Its mechanisms are unclear and it lacks effective therapy. Thrombospondin 1 (TSP1) mediated transforming growth factor-β1 (TGF-β1) activation was confirmed to promote renal fibrosis. Recently, a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13 (ADAMTS13), was reported to inhibit Thrombospondin 1 (TSP1) mediated Ca

Indexed as

ADAMTS13 ProteinKidneySmad3 ProteinThrombospondin 1Transforming Growth Factor beta1AnimalsCell LineDisease Models, AnimalFemaleFibrosisHumansMaleMiceMice, Inbred C57BLMiddle AgedSignal TransductionADAMTS13 ProteinADAMTS13 protein, humanSmad3 ProteinSMAD3 protein, humanSmad3 protein, mouseTGFB1 protein, humanThrombospondin 1thrombospondin-1, humanTransforming Growth Factor beta1ADAMTS13Renal fibrosisTGF-β1Thrombospondin 1Unilateral ureteral obstruction

Identifiers

PMID39929281
PMCPMC11877307

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.