Evidence map›Paper›PMID 39929081›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025

Role of α1 adrenergic receptors in the cerebral cortical blood flow response to acute hypoxia in low- and high-altitude near-term fetal lambs.

Jacqueline Bierwirth, John B Tan, Bobby D Mendez Padilla, Lubo Zhang, Hobe Schroeder, Taiming Liu, Gordon G Power, Arlin B Blood

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jacqueline BierwirthDivision of Neonatology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, United States.
John B TanDivision of Neonatology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, United States.
Bobby D Mendez PadillaLawrence D. Longo MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, United States.
Lubo ZhangLawrence D. Longo MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, United States.
Hobe SchroederLawrence D. Longo MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, United States.
Taiming LiuDivision of Neonatology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, United States.
Gordon G PowerLawrence D. Longo MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, United States.
Arlin B BloodDivision of Neonatology, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California, United States.ORCID 0000-0002-4803-5021

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Mechanisms of uterine artery hemodynamics adaptation to pregnancy and gestational hypoxiaR01HL169157 · NHLBI · LOMA LINDA UNIVERSITY · PI Arlin B Blood, Lubo Zhang · 2023 to 2026
$3.2M
Mechanisms of newborn pulmonary hypertension caused by chronic intrauterine hypoxiaR01HL155295 · NHLBI · LOMA LINDA UNIVERSITY · PI BLOOD, ARLIN B, WILSON, SEAN M · 2022 to 2025
$3.1M
Gestational Hypoxia and Programming of Maternal, Fetal and Newborn Vascular FunctionR01HL149608 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J., WILSON, SEAN M · 2020 to 2023
$3.1M
NHLBI NIH HHS R01 HL149608NHLBI NIH HHS R01 HL155295NHLBI NIH HHS R01 HL169157NICHD NIH HHS P01 HD083132NIH HHS HL149608NIH HHS HL155295
6 · The paper itself

Abstract

Fetal cerebral blood flow increases in response to acute hypoxia, mediated in part by an adrenergic α

Indexed as

AltitudeCerebral CortexCerebrovascular CirculationFetal HypoxiaHypoxiaReceptors, Adrenergic, alpha-1Adrenergic alpha-1 Receptor AntagonistsAnimalsFemalePrazosinPregnancySheepVascular ResistanceVasoconstrictionAdrenergic alpha-1 Receptor AntagonistsPrazosinReceptors, Adrenergic, alpha-1adrenergiccerebral blood flowfetushigh altitudehypoxia

Identifiers

PMID39929081
PMCPMC12315022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.