Evidence map›Paper›PMID 39928961›Full record

ArticlePhysiological genomics2025

Vacuole membrane protein 1 and acute response to renal ischemia and ischemia/reperfusion.

Vaishali Singh, Ryan J Adam, Mark R Paterson, Alison J Kriegel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Vaishali SinghDepartment of Pediatrics, Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Ryan J AdamDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Mark R PatersonDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Alison J KriegelDepartment of Pediatrics, Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-3961-9893

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
miRNA Mediated Cross-Talk in CRS4: The Role of the miR-21-5p/PPAR-Alpha PathwayR01HL128332 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI KRIEGEL, ALISON J · 2016 to 2020
$1.9M
A. O. Smith Foundation (AO Smith Foundation)HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL128332HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL134643NHLBI NIH HHS R01 HL128332NHLBI NIH HHS T32 HL007852NHLBI NIH HHS T32 HL134643
6 · The paper itself

Abstract

Ischemia-reperfusion (I/R) injury is an important initiating cause of chronic kidney disease and renal failure. Changes in proximal tubule (PT) morphology, including brush border loss, occur rapidly in response to ischemic stress and I/R injury. Vacuole membrane protein 1 (VMP1) is a compelling target for ischemia-associated renal damage because it is a necessary regulator of autophagy, and the genomic location of hypoxia-responsive microRNA

Indexed as

IschemiaKidneyMembrane ProteinsReperfusion InjuryAnimalsAutophagyKidney Tubules, ProximalMaleMicroRNAsRatsRats, Sprague-DawleyUp-RegulationMembrane ProteinsMicroRNAsautophagymiR-21proximal tubulerenal ischemia reperfusion injuryVMP1

Identifiers

PMID39928961
PMCPMC12264979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.