Evidence map›Paper›PMID 39928875›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses.

Benjamin W Neuman, Alexandria Smart, Orian Gilmer, Redmond P Smyth, Josef Vaas, Nicolai Böker, Dmitry V Samborskiy, Ralf Bartenschlager, Stefan Seitz, Alexander E Gorbalenya and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Discovery of the order 'Virus evolution · 2026
    Article
  7. Article
  8. Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. How nidoviruses evolved the largest known RNA genomes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Benjamin W Neuman *Department of Biology, Microbial Pathogenesis and Immunity, Texas A&M University, College Station, TX 77840.ORCID 0000-0003-1240-8954
Alexandria Smart *Helmholtz Institute for RNA-Based Infection Research, Helmholtz Centre for Infection Research, Würzburg 97080, Germany.
Orian Gilmer *Helmholtz Institute for RNA-Based Infection Research, Helmholtz Centre for Infection Research, Würzburg 97080, Germany.ORCID 0000-0002-7968-2133
Redmond P Smyth *Helmholtz Institute for RNA-Based Infection Research, Helmholtz Centre for Infection Research, Würzburg 97080, Germany.
Josef VaasDivision of Virus-Associated Carcinogenesis (F170), German Cancer Research Center, Heidelberg 69120, Germany.
Nicolai BökerInstitute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, a Joint Venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.
Dmitry V SamborskiyBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119899, Russia.ORCID 0009-0004-1340-7165
Ralf BartenschlagerDivision of Virus-Associated Carcinogenesis (F170), German Cancer Research Center, Heidelberg 69120, Germany.
Stefan SeitzDivision of Virus-Associated Carcinogenesis (F170), German Cancer Research Center, Heidelberg 69120, Germany.
Alexander E GorbalenyaLeiden University Center of Infectious Diseases, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.ORCID 0000-0002-4967-7341
Neva CaliskanHelmholtz Institute for RNA-Based Infection Research, Helmholtz Centre for Infection Research, Würzburg 97080, Germany.ORCID 0000-0003-0435-4757
Chris LauberInstitute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, a Joint Venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.ORCID 0000-0002-2265-2953

Funding

Deutsche Forschungsgemeinschaft (DFG) EXC 2155 - project number 390874280EC | European Research Council (ERC) project number 948636Helmholtz Association KA1-Co-02 "CoViPa"
6 · The paper itself

Abstract

Positive-strand RNA viruses of the order

Indexed as

Genome, ViralNidoviralesProteomeRNA, ViralAnimalsGenome SizeHost-Pathogen InteractionsPhylogenyProtein BiosynthesisViral ProteinsVirus ReplicationProteomeRNA, ViralViral Proteinscoronavirus genomicsdata-driven virus discoverynidovirus evolutionprogrammed ribosomal frameshiftingRNA genome expansion

Identifiers

PMID39928875
PMCPMC11848433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.