Evidence map›Paper›PMID 39928872›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins.

Martin F Arlt, Alyssa N Kruger, Callie M Swanepoel, Jacob L Mueller

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Signatures of sex ratio distortion in humans.bioRxiv : the preprint server for biology · 2026
    Article
  4. The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026
    Article
  5. Sex ratio drive in mice: A binding competition between sex-linked genes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Martin F ArltDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109.
Alyssa N KrugerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109.
Callie M SwanepoelDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0003-3857-626X
Jacob L MuellerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0003-1232-0303

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
Michigan Predoctoral Training in GeneticsT32GM149391 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN V. MORAN · 2024 to 2026
$2.2M
Roles of X- and Y-palindromic Genes in Mammalian FertilityR01HD094736 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUELLER, JACOB L · 2018 to 2022
$1.8M
Tracking the Rapid Evolution of Sex Chromosome Palindromes and Their GenesF31HD104339 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANEPOEL, CALLIE · 2021 to 2023
$127k
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD094736HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD104339HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM149391National Science Foundation (NSF) 1941796NICHD NIH HHS F31 HD104339NICHD NIH HHS R01 HD094736NICHD NIH HHS T32 HD079342NIGMS NIH HHS T32 GM007544NIGMS NIH HHS T32 GM149391NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) 1256260
6 · The paper itself

Abstract

The house mouse X and Y chromosomes have recently acquired multicopy, rapidly evolving gene families representing an evolutionary arms race. This arms race between proteins encoded by X-linked

Indexed as

Cell Cycle ProteinsEvolution, MolecularMicrotubule-Associated ProteinsMicrotubule ProteinsPhosphoproteinsSaccharomyces cerevisiaeAnimalsMiceProtein BindingX ChromosomeCell Cycle ProteinsMicrotubule-Associated ProteinsMicrotubule ProteinsPhosphoproteinsspindlinevolutionary arms racemulticopy genesprotein competitionssex chromosomesyeast two-hybrid

Identifiers

PMID39928872
PMCPMC11848428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.