ArticlePloS one2025
The effects of flight training on flying cadets' brain structure.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Human limits in next-generation fighter aviation: psychophysiological stressors, readiness, health, performance, and countermeasures.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the impact of professional training on brain structure has sparked extensive research interest. Research into pilots as a high-demand, high-load, and high-cost occupation holds significant academic and economic value. The aim of this study is to investigate the effects of flight training on the brain structure and cognitive functions of flying cadets. The structural magnetic resonance imaging (sMRI) data from 39 flying cadets and 37 general college students underwent analysis using voxel-based morphometry (VBM) and surface-based morphometry (SBM) methods to quantitatively detect and compute multiple indicators, including gray matter volume (GMV), curvature, mean curvature of the white matter surface (MC-WMS), the percentage of surface white matter gray matter (WM-GM percentage), surface Jacobi (S-Jacobi), and Gaussian curvature of white matter surface (GC-WMS). At the voxel level, the GMV in the left temporal pole: middle temporal gyrus region of flying cadets significantly decreased (Gaussian random field, GRF, P < 0.05). At the surface level, there was a significant increase in curvature, MC-WMS, and S-Jacobi in the lateral occipital region of flight cadets (Monte Carlo block level correction, MCBLC, P<0.05), a significant increase in WM-GM percentage in the cuneus region of flight cadets (MCBLC, P<0.05), and a significant increase in GC-WMS in the middle temporal region of flight cadets (MCBLC, P<0.05). In addition, these changes were correlated with behavioral tests. Research suggested that flight training might induce changes in certain brain regions of flying cadets, enabling them to adapt to evolving training content and environments, thereby enhancing their problem-solving and flight abilities. By analyzing multiple indicators at the voxel and surface levels in an integrated manner, it advances our understanding of brain structure, function, and plasticity, while also facilitating a more profound exploration of the neural mechanisms within the pilot's brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.