ArticleThe Plant cell2025
Melatonin confers saline-alkali tolerance in tomato by alleviating nitrosative damage and S-nitrosylation of H+-ATPase 2.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3-IFI6 Circuit in Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genome-wide transcriptional analysis of 14-3-3 genes in Paulownia fortunei under abiotic and biotic stresses.BMC plant biology · 2026Article
- Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S-Nitrosylation of MEK1.Plant biotechnology journal · 2026Article
- Plant-Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two-Component System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparative genome-wide identification and analysis of the COMT gene family in potato (Solanum tuberosum L.) and Arabidopsis ( Arabidopsis thaliana (L.) Heynh.).BMC plant biology · 2026Article
- Nitric Oxide Enhances Drought Tolerance inPlants (Basel, Switzerland) · 2026Article
- Tomato NAC2-DREB2 module fine-tunes saline-alkali stress sensitivity via modulation of melatonin biosynthesis and ROS homeostasis.Horticulture research · 2026Article
- MT@SiOPlant biotechnology journal · 2026Article
- Salt-stress-induced tomato sweetening involves an SlSnRK2.6-SlZHD8 sugar accumulation cascade triggered by root-derived abscisic acid.The EMBO journal · 2026Article
- Nitric oxide donor CySNO promotes plant growth and alleviates drought stress in soybean via antioxidant defense and transcriptional regulation.BMC plant biology · 2026Article
- Large-scale plant genomic identification and analysis uncoverHorticulture research · 2026Article
- SlNAC63-SlbHLH71 module enhances tomato saline-alkali tolerance via regulating JA biosynthesis and ROS scavenging.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Tomato antiviral ubiquitin-proteasome system recognizes viral 59 kDa protein to confer tomato chlorosis virus resistance.Nature communications · 2026Article
- The regulatory roles of flavonoids, melatonin, and glycine betaine in plant salt stress response.Frontiers in plant science · 2026Review
- Nitrogen use efficiency in crops under salt stress: from molecular networks to intelligent breeding.Frontiers in plant science · 2026Review
- Protein Post-Translational Modifications in Plant Abiotic Stress Responses.Plants (Basel, Switzerland) · 2025Review
- The Central Role of GSNOR: Decoding Nitric Oxide Signaling for Crop Stress Tolerance.International journal of molecular sciences · 2025Review
- Functional 14-3-3 Proteins: Master Regulators in Plant Responses to Salt Stress.Plants (Basel, Switzerland) · 2025Review
- Review
- Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses.Plant communications · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Soil salinization and alkalization disrupt redox homeostasis, impairing plant survival and crop production. Disruption of redox homeostasis can cause accumulation of reactive nitrogen species, such as nitric oxide (NO), which causes nitrosative damage in which the properties of biomacromolecules are altered. It is unclear whether melatonin regulates NO homeostasis, thereby affecting plant saline-alkali tolerance. In tomato (Solanum lycopersicum), excess NO caused by saline-alkali stress resulted in nitrosative damage, which was alleviated by S-nitrosoglutathione reductase (GSNOR). Moreover, saline-alkali stress-triggered NO stimulated caffeic acid O-methyltransferase (COMT) transcription and melatonin biosynthesis to scavenge excess NO and alleviate nitrosative damage at the proteome level. Under saline-alkali stress, plasma membrane-localized H+-ATPase 2 (HA2) was S-nitrosylated at Cys206, impairing its interaction with 14-3-3 protein 1 (TFT1). HA2 S-nitrosylation resulted in reduced HA activity, H+ efflux, and saline-alkali tolerance. Conversely, COMT-generated melatonin alleviated HA2 S-nitrosylation, recovering its function and tomato saline-alkali tolerance. Therefore, we propose that melatonin and NO are redox switches of HA2 S-nitrosylation for saline-alkali tolerance. Under natural saline-alkali conditions, tomato productivity was improved by grafting with COMT-, GSNOR-, or HA2-overexpression rootstocks, or by generating nonnitrosylated HA2C206S mutants. By establishing the melatonin-NO-HA2 module, this study illuminates a molecular function of melatonin and suggests possible genetic engineering strategies to improve agriculture.
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