ArticleInvestigative ophthalmology & visual science2025
Photoreceptor Function and Structure in Retinal Areas With Intraretinal Hyperreflective Foci in Age-Related Macular Degeneration.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Interpreting Hyperreflective Foci in Age-Related Macular Degeneration: A Critical Review of Cell Origins, Evolving Terminology and Clinical Utility.Clinical & experimental ophthalmology · 2026Review
- Topographic associations of hyperreflective materials in diabetic retinopathy: a multimodal correlation with microvascular pathology, structural remodeling and systemic metabolic dysregulation.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Purpose: To assess retinal light sensitivity in regions with intraretinal hyperreflective foci (IHRFs) in eyes with intermediate age-related macular degeneration (AMD) and examine the photoreceptor structure in these areas using adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography (OCT). Methods: A retrospective analysis was conducted on 82 eyes of 57 subjects (age: 76.4 ± 7.0 years) with intermediate AMD. IHRFs were identified in OCT B-scans. Drusen and subretinal drusenoid deposits (SDDs) were evaluated using multimodal imaging. Photoreceptor structure was assessed with AOSLO, and choroidal and retinal thicknesses were measured in areas with IHRFs. In 16 eyes, mesopic and scotopic light sensitivities were compared in regions with and without IHRFs but with similar SDD/drusen load in the same eye. Results: Retinal areas with IHRFs had significantly reduced mesopic (17.19 ± 5.68 dB vs. 18.49 ± 5.35 dB, P = 0.0029) and scotopic (8.39 ± 5.67 dB vs. 9.72 ± 6.28 dB, P = 0.0096) light sensitivity compared to areas without IHRFs. AOSLO revealed disrupted cone photoreceptor structure in IHRF regions. Choroidal thickness beneath areas with IHRFs was thinner than in those without IHRFs (196.71 ± 73.31 µm vs. 202.37 ± 70.64 µm, P = 0.0211). Retinal thickness in regions with IHRFs was not significantly different from those without IHRFs (320.40 ± 31.16 µm vs. 316.92 ± 26.32 µm, P = 0.3537). Conclusions: IHRF presence is associated with localized reduced visual function and photoreceptor degeneration in intermediate AMD. Prospective studies are warranted to further investigate the mechanisms of photoreceptor and sensitivity loss in the context of IHRF.
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Registered trials
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