Evidence map›Paper›PMID 39928286›Full record

ReviewClinical journal of gastroenterology2025

Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the rectum.

Hiroyuki Fujimura, Atsushi Goto, Yuta Izumiya, Shunsuke Ito, Akiyoshi Tanaka, Hiroshi Itoh, Taro Takami

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroyuki FujimuraDepartment of Gastroenterology and Hepatology, Hagi Civil Hospital, 3460-3 Tubaki, Hagi, Yamaguchi, 758-0061, Japan. fuji0129@hagicvhp.jp.ORCID http://orcid.org/0009-0001-7427-9249
Atsushi GotoDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Yuta IzumiyaDepartment of Gastroenterology and Hepatology, Hagi Civil Hospital, 3460-3 Tubaki, Hagi, Yamaguchi, 758-0061, Japan.
Shunsuke ItoDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Akiyoshi TanakaDepartment of Surgery, Hagi Civil Hospital, 3460-3 Tubaki, Hagi, Yamaguchi, 758-0061, Japan.
Hiroshi ItohDepartment of Molecular Pathology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Taro TakamiDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 75-year-old man presented to our hospital complaining of abdominal distention. He underwent lower gastrointestinal endoscopic examination, which indicated a raised tumor of 20 mm in diameter in the sigmoid colon transition region of the rectum. Endoscopic mucosal resection was performed with the aims of treatment and diagnosis. Histopathological examination revealed a moderately differentiated adenocarcinoma with neuroendocrine carcinoma, which was classified as a mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). The tumor had highly invaded the submucosa and positive vertical margins. Computed tomography showed no obvious lymph node metastasis or distant metastasis, so the patient underwent high-level anterior resection of the remaining lesion. The final diagnosis was MiNEN, pT3(SS), INFb, Ly1c, V0, Pn1a, pPM0, pDM0, pRM0, pN1a, and pStage IIIb (TNM Classification of Malignant Tumors, 8th Edition). The patient is recurrence free at 3 years without postoperative adjuvant therapy. We report this case with a review of the literature.

Indexed as

AdenocarcinomaCarcinoma, NeuroendocrineNeoplasms, Complex and MixedRectal NeoplasmsAgedEndoscopic Mucosal ResectionHumansMaleMANECMiNENNEC

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.