ArticleDiscover oncology2025
Effect of long-stranded non-coding RNA-BANCR on the progression of thyroid papillary carcinoma and its mechanism.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Development of a clinically applicable prediction tool for lymph node metastasis in papillary thyroid carcinoma using lasso-logistic regression.BMC cancer · 2026Article
- A combined model integrating deep learning, radiomics, and clinical ultrasound features for predictingFrontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis study aims to investigate the role of BRAF-activated long non-coding RNA (BANCR) in papillary thyroid carcinoma (PTC) progression and its association with clinical and molecular characteristics.
methodsSixteen PTC patients were stratified into four groups (PTC, HT, HT-LNM, and PTC-LNM) based on cervical lymph node metastasis and concurrent Hashimoto's thyroiditis (HT) to explore BANCR expression and its relationship with immune-related factors and tumor microenvironment (TME). Functional assays, including Transwell invasion, colony formation, and CCK8 were performed to evaluate the biological effects of BANCR in PTC cell lines. Bioinformatics analysis further identified BANCR-related pathways and clinical relevance.
resultsBANCR expression was significantly reduced in PTC tissues compared to normal thyroid tissues and was inversely correlated with tumor grade, lymph node metastasis, and T stage. Overexpression of BANCR in PTC cell lines inhibited proliferation, invasion and migration. Bioinformatics analysis demonstrated significant associations between BANCR and immune cell infiltration, immune-related genes, and stromal scores.
conclusionsBANCR acts as a tumor suppressor in PTC, suppressing tumor growth and metastasis. These findings provide insights into BANCR's potential as a prognostic marker and therapeutic target in PTC.
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