Evidence map›Paper›PMID 39928174›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Isolation and Immunomodulatory Activity of Cyanidin-3-O-(3,6-O-dimalonyl-β-D-glucoside) from the Black Corncob (Zea mays L.) and its Effect on Gut Microbiota in Elderly Feces under Anaerobic Conditions in vitro.

Junjie Li, Zhe Zhao, Wenzhuo Liu, Chuanlai Du, Kun Yu, Jianhua Zeng, Qiang Zou, Guijie Chen, Mingchun Wang, Xiaoxiong Zeng and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Promiscuous Transferases Malonylate Furaneol Glucoside inJournal of agricultural and food chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junjie LiCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China.
Zhe ZhaoCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China.
Wenzhuo LiuCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China.
Chuanlai DuCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China.
Kun YuCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China.
Jianhua ZengCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China.
Qiang ZouYantai Science and Technology Innovation Promotion Center, Yantai, Shandong, 264000, China.
Guijie ChenState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences & Technology, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Mingchun WangState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences & Technology, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Xiaoxiong ZengCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
Chunxu ChenCollege of Food Engineering, Anhui Science and Technology University, Fengyang, Anhui, 233100, China. chenchunxu@njau.edu.cn.

Funding

Discipline Leader Development Program of Anhui Province DTR2024034Excellent Research and Innovation Team of Anhui Province 2024AH010007Excellent Talent project of Anhui Science and Technology University XJYXRC202101Graduate Education Quality Engineering Project of Anhui Higher Education Institutions 2023xscx134National Natural Science Foundation of China 31901617Natural Science Research Foundation of Department of Education of Anhui Province 2022AH040236Project of Science and Technology Innovation Team of Anhui Science and Technology University 2023KJCXTD003Stable Talent Personnel Project of Anhui Science and Technology University SPWD202101Top Talent Project of Department of Education of Anhui Province gxyqZD2021125Undergraduate Innovation and Entrepreneurship Training Program of Anhui Province S202310879233
6 · The paper itself

Abstract

Black corn (Zea mays L.), native to Latin America, has been cultivated for millennia and holds significant cultural and culinary importance. While anthocyanins are well-characterized flavonoids in black corn, acylated derivatives remain insufficiently explored. Here, this study isolated a cyanidin derivative with two malonyl groups from black corncobs, identified as cyanidin-3-O-(3,6-O-dimalonyl-b-D-glucoside) (C3GdM) by mass spectrometry. The effects of C3GdM on the gut microbiota of the elderly and its immunomodulatory activity were examined in vitro. The findings revealed that C3GdM markedly improved gut microbiota composition, promoting beneficial bacteria growth such as Bifidobacterium and Lactobacillus while suppressing harmful bacteria like Escherichia/Shigella. Correspondingly, C3GdM elevated the levels of short-chain fatty acids in the feces of the elderly. Additionally, C3GdM upregulated genes associated with anti-inflammatory responses and antioxidant capacity in the elderly gut microbiota. In lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, C3GdM reduced nitric oxide, tumor necrosis factor-a and interleukin-6, along with their mRNA expression. Thus, C3GdM is a promising candidate for remodeling gut microbiota in the aging population.

Indexed as

AnthocyaninsFecesGastrointestinal MicrobiomeGlucosidesImmunologic FactorsZea maysAgedAnimalsAntioxidantsFatty Acids, VolatileFemaleHumansMacrophagesMaleMiceRAW 264.7 CellsAnthocyaninsAntioxidantscyanidin-3-O-beta-glucopyranosideFatty Acids, VolatileGlucosidesImmunologic FactorsAnthocyaninsAnti-agingBlack corncobsCyanidin-3-O-(3,6-O-dimalonyl-β-D-glucoside)Gut MicrobiotaSCFAs

Identifiers

PMID39928174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.