ArticleAbdominal radiology (New York)2025
Evaluation of iron deposition in diabetic kidney disease using the kidney-to-muscle signal intensity ratio on routine MRI T2WI sequences.
Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multimodal Magnetic Resonance Imaging in Diabetic Kidney Disease: From Pathophysiological Insights to Clinical Applications.Diagnostics (Basel, Switzerland) · 2026Review
- Iron-Driven Ferroptosis in Diabetic Kidney Disease: From Molecular Mechanisms to Targeted Therapeutic Translation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe T2* technique in Blood Oxygen Level Dependent Magnetic Resonance Imaging (BOLD-MRI) has been established as a non-invasive standard for quantifying tissue iron levels. This study aims to assess the feasibility of obtaining quantitative iron-sensitive information from conventional MRI T2-weighted imaging (T2WI) sequences, typically used for anatomical rather than quantitative assessments, and to explore its potential as a routine monitoring tool for renal iron levels in diabetic kidney disease (DKD).
methodsA total of 142 patient imaging data from renal MRI scans were retrospectively analyzed. We measured the kidney and psoas major muscle signal intensity on T2WI sequences and calculated the kidney-to-muscle signal intensity ratio (K/M-SIR) to determine differences across patient groups. Relevant laboratory indices were collected to analyze the correlation between K/M-SIR and laboratory markers.
resultsWe included 42 clinically confirmed DKD patients, 47 patients with diabetes but no DKD, and 53 healthy subjects. The K/M-SIR was 2.66 ± 0.49 in DKD patients, 2.94 ± 0.51 in diabetic patients without DKD, and 2.95 ± 0.55 in healthy subjects. There were statistically significant differences in K/M-SIR between DKD patients and healthy subjects (p = 0.008) and between DKD patients and diabetic patients without DKD (p = 0.009). K/M-SIR values were negatively correlated with laboratory indices such as glycated hemoglobin (HbA1c), microalbuminuria (MAU), albumin-to-creatinine ratio (ACR), and 24-hour urinary protein (24 h UP).
conclusionThe kidney-to-muscle signal intensity ratio (K/M-SIR) derived from routine MRI T2WI sequences is valuable for diagnosing DKD and may serve as a reliable non-invasive marker for assessing renal iron deposition in DKD, potentially aiding in the diagnosis and monitoring of DKD severity.
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