Evidence map›Paper›PMID 39928073›Full record

ArticleAIDS and behavior2025

Impact of Peer Referral on Pre-Exposure Prophylaxis Adherence and Persistence Among Men Who Have Sex with Men: A Cohort Study in China.

Chengxin Fan, Zhuoheng Yin, Chunyan Li, Yifan Dai, Heping Zhao, Gifty Marley, Quanmin Li, Songjie Wu, Haojie Huang, Aniruddha Hazra and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chengxin FanSchool of Public Health, Nanjing Medical University, No. 101 Longmian St, Nanjing, 211166, China.
Zhuoheng YinUniversity of North Carolina Project-China, Guangzhou, China.
Chunyan LiTokyo College, The University of Tokyo, Tokyo, Japan.
Yifan DaiUniversity of North Carolina Project-China, Guangzhou, China.
Heping ZhaoInfectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Gifty MarleyUniversity of North Carolina Project-China, Guangzhou, China.
Quanmin LiInfectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Songjie WuDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Haojie HuangWuhan Tongxing LGBT Center, Wuhan, China.
Aniruddha HazraSection of Infectious Diseases and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA.
Jonathan LioSection of Infectious Diseases and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA.
Ke LiangDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Linghua LiInfectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Renslow ShererSection of Infectious Diseases and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA.
Joseph D TuckerUniversity of North Carolina Project-China, Guangzhou, China.
Weiming TangSchool of Public Health, Nanjing Medical University, No. 101 Longmian St, Nanjing, 211166, China. weiming_tang@med.unc.edu.ORCID http://orcid.org/0000-0002-9026-707X

Funding

Gilead Sciences CO-US-276-5866
6 · The paper itself

Abstract

Peer referral leverages social networks to connect individuals with health services, potentially enhancing pre-exposure prophylaxis (PrEP) use. This study aims to investigate the impact of peer referral on PrEP adherence and persistence among men who have sex with men (MSM) in China. This study is nested in a 12-month PrEP (FTC/TDF) demonstration trial in China from September 2021 to December 2023. Peer referral was defined as participants being referred by peers already enrolled in the trial. PrEP adherence was measured as taking four or more pills per week for daily users or following the 2 + 1 + 1 event-driven regimen at least 75% of the time. PrEP persistence was defined as the time from initiation to discontinuation. We collected data from the first 6 months of follow-up and used generalized estimating equations and Cox regression models to evaluate the association between peer referral and PrEP adherence and persistence. A total of 1,131 MSM initiated PrEP, with 121 (10.7%) referred by peers. At month 6, adherence rates were 75.0% for peer-referred MSM and 67.1% for non-peer-referred MSM. Peer-referred MSM had higher adherence than non-peer-referred MSM (aRR = 1.11, 95% CI: 1.01-1.22). Regarding persistence, 812 (71.8%) MSM continued using PrEP at 6 months of follow-up, and peer-referred MSM were more likely to persist with PrEP (aHR = 1.85, 95% CI: 1.17-2.91). These findings demonstrate the potential of peer referral in promoting PrEP use among MSM, suggesting the value of powerful peer-based interventions like peer navigation in future PrEP outreach.

Indexed as

Anti-HIV AgentsHIV InfectionsHomosexuality, MaleMedication AdherencePeer GroupPre-Exposure ProphylaxisReferral and ConsultationAdultChinaCohort StudiesHumansMaleMiddle AgedYoung AdultAnti-HIV AgentsAdherenceMen who have sex with men (MSM)Peer referralPersistencePre-exposure prophylaxis(PrEP)

Identifiers

PMID39928073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.