Evidence map›Paper›PMID 39928068›Full record

Trial reportAIDS and behavior2025

Impact of COVID-19-Related Disruptions on Antiretroviral Therapy Adherence Among Young Adults Living with HIV in Southern Uganda.

Abel Zemedkun Girma, Rachel Brathwaite, Yvonne Karamagi, Fatumah Nakabuye, Noeline Nakasujja, William Byansi, Proscovia Nabunya, Ozge Sensoy Bahar, Fred M Ssewamala

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01790373 (Suubi+Adherence), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01790373 naactive not recruitingnot on this map

Suubi+Adherence: Evaluating a Youth-Focused Economic Empowerment Approach to HIV Treatment Adherence

TypeinterventionalSponsorWashington University School of MedicineRan2013 to 2026Enrolled702ConditionsHIVArmsSuubi+Adherence, Bolstered Standard of Care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abel Zemedkun GirmaInternational Center for Child Health and Development, Brown School, Washington University, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0009-0000-3000-1037
Rachel BrathwaiteInternational Center for Child Health and Development, Brown School, Washington University, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0002-9363-3581
Yvonne KaramagiMildmay Uganda, 12 Km Entebbe Road, Naziba Hill, Lweza, Kampala, Uganda.
Fatumah NakabuyeBrown School, Washington University, St. Louis, MO, 63130, USA.
Noeline NakasujjaDepartment of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID http://orcid.org/0000-0002-8163-4376
William ByansiBoston College School of Social Work, 140 Commonwealth Avenue, Chestnut Hill, MA, 02467, USA.ORCID http://orcid.org/0000-0003-2880-9357
Proscovia NabunyaInternational Center for Child Health and Development, Brown School, Washington University, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0002-9088-5839
Ozge Sensoy BaharInternational Center for Child Health and Development, Brown School, Washington University, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0002-7230-0438
Fred M SsewamalaInternational Center for Child Health and Development, Brown School, Washington University, St. Louis, MO, 63130, USA. fms1@wustl.edu.ORCID http://orcid.org/0000-0002-4849-5650

Funding

Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthoodR01HD074949 · NICHD · WASHINGTON UNIVERSITY · PI NABUNYA, PROSCOVIA, SENSOY BAHAR, OZGE · 2012 to 2024
$7.7M
Child Mental Health in HIV-impacted Low-Resource Settings in Developing Countries: Global Research FellowshipD43TW011541 · FIC · WASHINGTON UNIVERSITY · PI MCKAY, MARY MCKERNAN, NAKASUJJA, NOELINE · 2020 to 2024
$1.7M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD074949FIC NIH HHS 3D43TW011541-02S1FIC NIH HHS D43 TW011541NICHD NIH HHS R01 HD074949
6 · The paper itself

Abstract

We investigated how COVID-19-related disruptions influenced antiretroviral therapy (ART) adherence among young adults living with HIV (YALHIV) in Southern Uganda, a region with limited resources and high rates of HIV. Data were analyzed from 499 YALHIV aged 19 to 25, participating in the Suubi+Adherence-R2 COVID-19 Supplement study. The study measured COVID-19 disruptions using an 8-item Coronavirus Impact Scale and evaluated ART adherence through self-reported measures. Our analytical framework was informed by the Health Belief Model and generalized estimating equations were estimated. We find no statistically significant association between COVID-19 disruptions, as quantified by the COVID-19 Impact Score, and sub-optimal ART adherence (OR = 0.99, 95% CI [0.87-1.14]). However, findings revealed that being employed (OR = 1.99, 95% CI [1.07-3.71]) and older age (OR = 1.18, 95% CI [1.02-1.37]) was associated with higher likelihood of poor adherence highlighting the complex interplay between economic activity, working schedules, and health management. Other notable predictors included marital status, with cohabiting individuals showing decreased odds of poor adherence (OR = 0.25, 95% CI [0.08-0.74]) compared to single and separated YALHIV. These insights emphasize the need for multifaceted intervention strategies that consider both individual and systemic factors affecting ART adherence. Tailored interventions must address the socioeconomic challenges intensified by the pandemic and leverage the inherent resilience within this population to enhance ART adherence outcomes for YALHIV in challenging environments. Trial Registration ClinicalTrials.gov, ID: NCT01790373.

Indexed as

Anti-HIV AgentsCOVID-19HIV InfectionsMedication AdherenceAdultFemaleHumansMaleSARS-CoV-2UgandaYoung AdultAnti-HIV AgentsART adherenceCOVID-19Health belief modelHIVYoung adults living with HIV

Identifiers

PMID39928068
PMCPMC12874465

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.