Evidence map›Paper›PMID 39927883›Full record

ArticleAging2025

Exploring the role of acylated ghrelin and gut microbiome in delineating cognitive health in the elderly.

Sudeshna Rout, Rishikesh Dash, Varsha Satish, Giriprasad Venugopal, Bodepudi Narasimha Rao, Debapriya Bandhyopadhyay, Sanjeev Kumar Bhoi, Balamurugan Ramadass

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In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sudeshna RoutDepartment of Biochemistry, All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Rishikesh DashCentre of Excellence for Clinical Microbiome and Research (CCMR), All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Varsha SatishCentre of Excellence for Clinical Microbiome and Research (CCMR), All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Giriprasad VenugopalCentre of Excellence for Clinical Microbiome and Research (CCMR), All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Bodepudi Narasimha RaoDepartment of Physiology, All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Debapriya BandhyopadhyayDepartment of Biochemistry, All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Sanjeev Kumar BhoiDepartment of Neurology, All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.
Balamurugan RamadassDepartment of Biochemistry, All India Institute of Medical Sciences Bhubaneswar, Odisha 751019, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWith increased life expectancy, there is an increase in aging population and prevalence of dementia. Ghrelin is a key regulator of spatial memory and cognition. The gut microbiome may affect the circulating levels of unacylated ghrelin (UAG) and acylated ghrelin (AG). Thus, we explore the potential association of the gut microbiome, AG, and cognitive health in the aging dementia patient.

methods40 dementia patients and 40 controls were recruited. Fecal Microbiome analysis using 16S rRNA sequencing was performed on 18 samples. A mixed-method approach was employed for robust interpretation.

resultsDementia patients had an increased serum AG and AG/UAG ratio. With the increase in AG among dementia subjects, a significant decrease in species richness was observed. DISCUSSION: This pilot study indicates a complex interaction between AG, gut microbiome, and cognitive scores. Increased AG corresponds to both dementia and gut dysbiosis, intricately interconnecting the gut-brain axis. The circulating AG and associated gut microbiome might be a putative biomarker for dementia.

Indexed as

AgingCognitionDementiaGastrointestinal MicrobiomeGhrelinAcylationAgedAged, 80 and overCase-Control StudiesFecesFemaleHumansMalePilot ProjectsRNA, Ribosomal, 16SGhrelinRNA, Ribosomal, 16SAG/UAG ratiodementiaghrelingut-brain axisgut microbiomeneural network model

Identifiers

PMID39927883
PMCPMC11892914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.