Evidence map›Paper›PMID 39927867›Full record

ReviewInternational forum of allergy & rhinology2025

Expert Consensus on Surgical Management of Primary Diffuse Type 2-Dominant Chronic Rhinosinusitis.

Manon Blauwblomme, Christos Georgalas, Shahzada Ahmed, Isam Alobid, Paolo Battaglia, Paolo Castelnuovo, Jannis Constantinidis, Iacopo Dallan, Anne-Sophie Eeckels, Marco Ferrari and 13 more

Abstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Manon BlauwblommeDepartment of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-6263-4883
Christos GeorgalasDepartment of Otorhinolaryngology Head and Neck Surgery, University of Nicosia Medical School, Nicosia, Cyprus.ORCID 0000-0003-1158-020X
Shahzada AhmedDepartment of ENT and Skull Base Surgery, Birmingham Hospital, Birmingham, UK.
Isam AlobidENT Department, Rhinology and Skull Base Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, August Pi i Sunyer Biomedical Research Institute, CIBERES, Barcelona, Spain.
Paolo BattagliaDepartment of Otolaryngology Head and Neck Surgery, Department of Biotechnology and Life Sciences, ASST Lariana, Ospedale Sant'Anna, University of Insubria, Varese, Italy.
Paolo CastelnuovoDepartment of Otorhinolaryngology Head and Neck Surgery, Department of Biotechnology and Life Sciences, Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi, University of Insubria, Varese, Italy.
Jannis ConstantinidisDepartment of Otorhinolaryngology Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Iacopo DallanHead and Neck Surgery and Forensic Dissection Research Center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Anne-Sophie EeckelsDepartment of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.
Marco FerrariSection of Otorhinolaryngology Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, Italy.
Philippe GevaertDepartment of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.
Jessica GraysonDepartment of Otolaryngology, University of Alabama Birmingham, Birmingham, Alabama, USA.
Richard HarveyRhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.
Philippe HermanDepartment of Head and Neck Surgery, Université Paris Cité, Lariboisière Hospital, Paris, France.
Iordanis KonstantinidisDepartment of Otorhinolaryngology Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Darlene LubbeDivision of Otolaryngology, University of Cape Town Faculty of Health Sciences, Cape Town, South Africa.
Cem MecoDepartment of Otolaryngology Head and Neck Surgery, Ankara University Medical School, Ankara, Turkey.
James PalmerDepartment of Otolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zara M PatelDepartment of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-2072-982X
Agnieszka StrzemboszOtorhinolaryngology Division, Department of Surgery, Medicover Hospital, Warsaw, Poland.
Benjamin VerillaudDepartment of Head and Neck Surgery, Université Paris Cité, Lariboisière Hospital, Paris, France.
Bradford A WoodworthDepartment of Otolaryngology, University of Alabama Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-3292-9167
Thibaut Van ZeleDepartment of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0002-6031-4293

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic rhinosinusitis (CRS) poses significant challenges in surgical management due to the lack of clear guidelines, particularly in type 2 CRS. This review focuses on surgical approaches for primary diffuse type 2-dominant CRS, emphasizing preoperative and intraoperative strategies.

methodsA consensus group, comprising experts from Europe, United Kingdom, Australia, South Africa, North and South America, was assembled. Using a modified Delphi method, 67 statements were formulated following a literature review, with an additional statement added in the second iteration. Final recommendations were discussed during a consensus meeting in Santorini, Greece, in October 2023.

resultsOut of the 68 proposed statements, consensus was achieved on 45. Most (34) statements received a median score of 7 (strongly agree), and 11 had a median score of 6 (agree). The finalized recommendations cover the indications, timing, extent of surgery, and intraoperative management for both primary and revision surgery in primary diffuse type 2-dominant CRS. A key focus is on complete sinus surgery, which involves creating a neo-sinus cavity by removing bone partitions in the ethmoid and opening the frontal and sphenoidal sinuses as needed. Adequate primary and revision surgery includes clearing all nasal polyps and diseased mucosa while ensuring ideal conditions for topical therapy. Additionally, there was consensus on performing complete sinus surgery before considering monoclonal antibody therapies, unless contraindicated.

conclusionThese 45 consensus statements, derived from both current evidence and expert opinion, provide valuable guidance for clinicians in the surgical management of primary diffuse type 2-dominant CRS.

Indexed as

Paranasal SinusesRhinitisSinusitisChronic DiseaseHumansRhinosinusitisconsensus statementsDelphi methodendoscopic sinus surgeryextent of surgerynasal polypsrevision surgery

Identifiers

PMID39927867
PMCPMC11872782

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.