Evidence map›Paper›PMID 39927783›Full record

ArticleAntimicrobial agents and chemotherapy2025

Cefepime-taniborbactam and ceftibuten-ledaborbactam maintain activity against KPC variants that lead to ceftazidime-avibactam resistance.

Cullen L Myers, Annie Stevenson, Brittany Miller, Denis M Daigle, Tsuyoshi Uehara, Daniel C Pevear

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Antimicrobial agents and chemotherapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cullen L MyersDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0002-5789-2260
Annie StevensonVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.
Brittany MillerVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.
Denis M DaigleVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.ORCID 0000-0001-9287-2997
Tsuyoshi UeharaVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.ORCID 0000-0001-6994-4286
Daniel C PevearVenatorx Pharmaceuticals Inc., Malvern, Pennsylvania, USA.

Funding

Development of New Beta-Lactamase Inhibitors for Resistant Category B Food/Water-R01AI089512 · NIAID · VENATORX PHARMACEUTICALS, INC. · PI BURNS, CHRISTOPHER JOHN · 2010 to 2012
$4.1M
NIAID NIH HHS HHSN272201300019CNIAID NIH HHS HHSN272201300019INIAID NIH HHS R01 AI089512Wellcome TrustWellcome Trust 101999/Z/13/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamasesCefepimeCeftazidimeCephalosporinsKlebsiella pneumoniaeBacterial ProteinsBorinic AcidsCarboxylic AcidsDrug CombinationsHeterocyclic Compounds, 1-RingHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactamavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-lactamase KPC-2beta-LactamasesBorinic AcidscarbapenemaseCarboxylic AcidsCefepimeCeftazidimeCephalosporinsDrug CombinationsHeterocyclic Compounds, 1-Ringtaniborbactamantibiotic resistanceceftazidime–avibactamKPCledaborbactamtaniborbactamβ-lactamase inhibitor

Identifiers

PMID39927783
PMCPMC11881561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.