ReviewACS applied bio materials2025
Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review.
Review in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Next-generation epidermal patches: Bridging 3D and multidimensional printing for biomedical and personal care innovations.Bioactive materials · 2026Review
- Traditional Chinese medicine ingredients integrated microneedles: A promising strategy for transdermal treatment.Asian journal of pharmaceutical sciences · 2026Review
- Recent Advances in Integrating Graphene into Polymeric Nanocomposite Hydrogels for Biomedical Applications.Macromolecular bioscience · 2026Review
- Advances in 3D Printed Microneedles as a Prototype for Skin Targeted Therapeutics in Personalized Dermal Pharmaceuticals.AAPS PharmSciTech · 2025Review
- Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems.International journal of nanomedicine · 2025Review
- Wearable armband with a floating mobile exploratory electrode at fingertip for on-demand touch-and-measure multilead electrocardiography.Wearable technologies · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transdermal drug delivery presents a promising noninvasive approach, bypassing first-pass metabolism and gastrointestinal degradation. However, the stratum corneum (SC) barrier limits drug absorption, necessitating the development of effective delivery systems. Microneedles, particularly polymer-based ones, offer a solution by penetrating the SC while avoiding critical nerves and capillaries. These microneedles are biodegradable, nontoxic, and easily manufacturable, making them a highly attractive platform for transdermal drug delivery. However, their clinical application remains limited due to suboptimal therapeutic efficacy and slow drug release rates. Recent advancements have introduced the incorporation of nanodrugs, such as nanoparticles and encapsulated drugs, into microneedles to enhance drug delivery efficiency. Among the materials explored, graphene and its derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), have garnered significant attention. Their exceptional mechanical strength, electrical conductivity, and antibacterial properties not only improve the mechanical performance of microneedles but also enhance drug release rates and biocompatibility. This review synthesizes the current state of microneedle technologies, focusing on the materials, fabrication techniques, and performance challenges. It particularly examines the potential of graphene-based microneedles, comparing them to traditional polymer-based microneedles in terms of drug release efficiency and stability. The review highlights key challenges, such as scalability, biocompatibility, and fabrication complexity, and suggests future research directions to address these issues. The incorporation of graphene quantum dots (GQDs) is identified as a promising avenue for improving drug release profiles, stability, and real-time tracking of drug diffusion. Finally, the review outlines emerging applications, including smart drug delivery systems, biosensing, and real-time monitoring, urging further exploration to unlock the full potential of graphene-enhanced microneedles in clinical settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.