Evidence map›Paper›PMID 39927617›Full record

ReviewChemical reviews2025

The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids.

Lei Du, Longyang Dian, Sean A Newmister, Yuwei Xia, Guanzhong Luo, David H Sherman, Shengying Li

Abstract readReview
In one paragraph

Review in Chemical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lei DuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.ORCID 0000-0003-2245-7100
Longyang DianState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
Sean A NewmisterLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Yuwei XiaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
Guanzhong LuoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
David H ShermanLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8334-3647
Shengying LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.ORCID 0000-0002-5244-870X

Funding

Discovery and Characterization of Natural Product Systems-Research Supplement to Promote DiversityR35GM118101 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHERMAN, DAVID H · 2016 to 2025
$3.3M
NIGMS NIH HHS R35 GM118101
6 · The paper itself

Abstract

Fungal indole alkaloids bearing a bicyclo[2.2.2]diazaoctane (BCDO) core structure are a fascinating family of natural products that exhibit a wide spectrum of biological activities. These compounds also display remarkable structural diversity, with many different diastereomers and enantiomers produced by specific fungal strains. The biogenesis of the unique BCDO moiety has long been proposed to involve an intramolecular [4+2]

Indexed as

FungiIndole AlkaloidsBiological ProductsBiological ProductsIndole Alkaloids

Identifiers

PMID39927617
PMCPMC11936112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.