Evidence map›Paper›PMID 39927594›Full record

ArticleMolecular pharmaceutics2025

Evaluation of a Novel Gd-FAPI Dimer Molecular Probe Targeting Fibroblast Activation Protein for Imaging of Solid Tumors.

Xiaohui Wang, Caiyu Zhuang, Xinhui Zheng, Xiaolei Zhang, Zhijian Han, Renhua Wu

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaohui WangDepartment of Nuclear Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, China.ORCID 0009-0009-6296-0182
Caiyu ZhuangRadiology Department, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.ORCID 0000-0001-7310-0756
Xinhui ZhengRadiology Department, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Xiaolei ZhangRadiology Department, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Zhijian HanKey Laboratory of Digestive System Tumors of Gansu Province, The Second Hospital of Lanzhou University, Lanzhou 730000, China.ORCID 0000-0002-3045-0913
Renhua WuRadiology Department, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment. Fibroblast activation protein (FAP) is overexpressed in CAFs. FAP-targeted molecular imaging agents, including the FAP inhibitors (FAPIs), have shown promising results in tumor diagnosis. We aimed to design a Gd-labeled FAPI Dimer, Gd-DOTA-Suc-Lys-(FAPI04)

Indexed as

GadoliniumGelatinasesMembrane ProteinsMolecular ProbesNeoplasmsSerine EndopeptidasesAnimalsCancer-Associated FibroblastsCell Line, TumorContrast MediaEndopeptidasesFemaleFibroblast Activation Protein AlphaHumansMagnetic Resonance ImagingMiceContrast MediaEndopeptidasesFibroblast Activation Protein AlphaGadoliniumGelatinasesMembrane ProteinsMolecular ProbesSerine Endopeptidasesfibroblast activation protein inhibitorsmagnetic resonance imagingmolecular imaging

Identifiers

PMID39927594
PMCPMC11881143

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.