Evidence map›Paper›PMID 39927581›Full record

Observational studyRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia2025

Epidemiological characteristics of antimicrobial use in Primary Care in Spain: a nationwide study.

Héctor Sánchez-Herrero, Álvaro Solaz-García, Alejandro Pinilla-González, Elena Vanessa Martínez-Sánchez, Patricia Santágueda-Balader, María Cernada-Badía

Abstract readObservational Study
In one paragraph

Observational study in Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trends in antifungal use characteristics in primary care in Spain, 2019 to 2024: a nationwide study.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Héctor Sánchez-HerreroCoordinating Center for Health Alerts and Emergencies, Ministry of Health, Spain; Research group of Nursing and Health Care, IDIPHISA, Spain.ORCID 0000-0003-0734-1695
Álvaro Solaz-GarcíaUniversity and Polytechnic La Fe Hospital of Valencia, Spain; Research group of Perinatology. Health Research Institute La Fe (IISLAFE), Spain. solaz_alv@gva.es.ORCID 0000-0001-6713-8408
Alejandro Pinilla-GonzálezUniversity and Polytechnic La Fe Hospital of Valencia, Spain; Research group of Perinatology. Health Research Institute La Fe (IISLAFE), Spain.ORCID 0000-0003-3358-245X
Elena Vanessa Martínez-SánchezCoordinating Center for Health Alerts and Emergencies, Ministry of Health, Spain.ORCID 0000-0003-1620-7113
Patricia Santágueda-BaladerTragsatec, Coordinating Center of Health Alerts and Emergencies, Ministry of Health, Spain.
María Cernada-BadíaUniversity and Polytechnic La Fe Hospital of Valencia, Spain; Research group of Perinatology. Health Research Institute La Fe (IISLAFE), Spain.ORCID 0000-0001-8861-6384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aims to describe antimicrobial use in primary care across Spain by analyzing the prescriptions dispensed in pharmacies. Antimicrobials were categorized into therapeutic action groups based on the ATC-2 classification: antibacterials (J01), antimycotics (J02), antimycobacterials (J04), and antivirals (J05). Additionally, the study explores epidemiological patterns of use.

methodsA retrospective observational study was conducted using data from the Primary Care Clinical Database (BDCAP) for 2023. The analysis focused on defined daily doses (DDD) per 1,000 persons/day (DHD), and the number of individuals with at least one antimicrobial prescription in primary care. Data were stratified by age, sex, municipality size, income level, country of birth, and employment status. Changes in prescriptions percentages in 2017 and 2023, as well as variations by age group and sex were compared.

resultsAn overall upward temporal trend in the antimicrobial DHD was observed from 2017 to 2023 (increase of 20.2%), with a decrease in usage during 2020 and 2021. Women exhibited higher DHD for antibacterials, antimycotics, and antivirals, whereas men demonstrated higher DHD for antimycobacterials. Notably, antimycobacterial agents had higher DHD in municipalities with populations exceeding 100,000 inhabitants and among foreign-born individuals. Out of 46,762,487 people assigned to primary care, 14,056,450 received prescribed antimicrobials in 2023.

conclusionsThese findings indicate a rising trend in antimicrobial use in primary care, underscoring the need for targeted interventions to encourage the rational use of antimicrobials, particularly in high-use groups.

Indexed as

Anti-Infective AgentsDrug UtilizationPractice Patterns, Physicians'Primary Health CareAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsChildChild, PreschoolDrug PrescriptionsFemaleHumansInfantInfant, NewbornAnti-Bacterial AgentsAnti-Infective AgentsAntibacterialsAntibioticsAntifungalsAntimicrobial resistanceAntimicrobialsAntimicrobial stewardshipAntimycobacterialsAntimycoticsAntiviralsPrimary care

Identifiers

PMID39927581
PMCPMC11894558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.