Evidence map›Paper›PMID 39927553›Full record

ReviewCytoskeleton (Hoboken, N.J.)2025

TRiC Is a Structural Component of Mammalian Sperm Axonemes.

Alan Brown, Miguel Ricardo Leung, Tzviya Zeev-Ben-Mordehai, Rui Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alan BrownDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Miguel Ricardo LeungHubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, the Netherlands.
Tzviya Zeev-Ben-MordehaiStructural Biochemistry Group, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, the Netherlands.
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.

Funding

Nederlandse Organisatie voor Wetenschappelijk OnderzoekNIH HHSRichard and Susan Smith Family Foundation
6 · The paper itself

Abstract

The TRiC chaperonin is responsible for folding ~5%-10% of the proteome in eukaryotic cells. Our recent cryo-electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial spokes of doublet microtubules. In contrast, axoneme-tethered TRiC is not observed in mammalian epithelial cilia, nor in any of the non-mammalian sperm flagella studied to date. In this Perspective, we explore several hypotheses for the potential functions of axoneme-tethered TRiC in mature sperm.

Indexed as

AxonemeChaperonin Containing TCP-1SpermatozoaSperm TailAnimalsHumansMaleMammalsChaperonin Containing TCP-1axonemeschaperonincryo‐EMspermTRiC

Identifiers

PMID39927553
PMCPMC12701526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.