ArticleOpen veterinary journal2024
Acute toxicity effects of ethylene glycol on lethal dose 50 (LD
Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Acute, high dose ethylene glycol administration produces no neuroinflammation, no abnormal brain or liver histology, significant urinary oxalate excretion, and minimal nephrotoxicity in male CD-1 mice.Toxicology reports · 2026Article
- Modulating effects of bee venom (Apis mellifera intermissa) against ethylene glycol-induced oxidative nephrotoxicity in male mice.International urology and nephrology · 2026Article
- Evaluation of the Anti-Liver Cancer Activity of Protein Fractions Isolated fromProtein and peptide letters · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The LD Aim: This study aimed to determine the acute toxicity of an oral lethal dose of 50% (LD Methods: There were 66 DDG (Deutschland Denken Yoken) mice in 11 groups of six in this investigation. The daylong metabolic cage study contained one control (C) and 10 treatment groups that received different EG doses. EG's daily BW/kg dosage varied from 0.5 mg/kg to 15,000 mg/kg. The treatment group was given a single dose of EG at a dose of T1 = 0.5 mg/kg BW, T2 = 1.57 mg/kg BW, T3 = 4.94 mg/kg BW, T4 = 15.54 mg/kg BW, T5 = 48.84 mg/kg BW, T6 = 153.55 mg/kg BW, T7 = 482.74 mg/kg BW, and T8 = 1517.66 mg/kg BW T9 = 4771.24 mg/kg BW, T10 = 14999.99 ≈ 15. 000 mg/kg BW. One-way Analysis of Variance testing was used to analyze the data. Results: The LD Conclusion: Acute EG exposure caused renal failure in male mice. Acute exposure to EG causes renal tubular cell degeneration and inflammation, indicating toxicity and health hazards.
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Registered trials
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