The potential of fruit ethanolic extract

Background: Leaf ethanolic extract of Aim: This study evaluated the potential of FE3H as a solution for hyperglycemia, uremia, and hypercreatininemia in mice. Methods: Quercetin levels in FE3H were determined by high-performance liquid chromatography. The first (A) stage used 25 male mice divided into five groups. On day (d)1, the body weight (BW) of the mice was weighed. On d2-11, 5-mg/gBW sucrose was given by gavage, and then, on d12, BW and blood glucose level of mice were determined. On d13, 0.52-mg/gBW glibenclamide was given in A2, 0.39-mg/gBW FE3H was given in A3, and 0.52-mg/g BW FE3H was given in A4 by gavage. Control, A0, was only given double-distilled water (DDW). On d14, BW and blood glucose levels of the mice were determined. The second (B) stage used 24 male mice divided into six groups. On d1, B1-B5 were injected intraperitoneally 5-mg/kg BW HgCl Results: FE3H contains 98.92 ± 12.88 µg/g quercetin. Sucrose tends to increase BW, and then, 0.39-mg/g BW FE3H treatment tends to restore BW close to control. Sucrose significantly increased blood glucose, and then, 0.39- and 0.52-mg/gBW FE3H treatment restored significantly blood glucose similar to control. HgCl Conclusion: FE3H, which is high in flavonoid quercetin, has the potential to restore hyperglycemia by 47.38%-48.18%, uremia by 29.04%-33.06%, and hypercreatininemia by 49.52%-54.28% in mice.