ArticleOpen veterinary journal2024
Direct and indirect effects of PGF2α administration in male Wistar rats based on increased expression of α-SMA and androgen receptor.
Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Prostaglandin F2α (PGF2α) hormone administration can improve semen quality through increased contractility of smooth muscle cells in testicular tissue and increased testosterone hormone. Immunohistochemically, the increase in contractility of smooth muscle cells and testosterone hormone can be measured by an increase in the expression of alpha-smooth muscle actin (α-SMA) and androgen receptor (AR). Aim: This study aims to determine the distribution and increased α-SMA expression and AR in the testis of Wistar rats after administration of PGF2α which was detected using the immunohistochemistry (IHC) method. Methods: A total of 15 male Wistar rats ( Results: The results showed that α-SMA was positively detected in peritubular myoid (PTM) cells on the basal membrane of seminiferous tubules, blood vessel (BV) walls, and connective tissue. Statistical analysis showed that α-SMA expression in PTM cells and testicular connective tissue in P2 (60-minute interval) was significantly different than other treatment groups (P0, P1, P3, and P4) ( Conclusion: It can be concluded that the administration of PGF2α increases the expression of α-SMA and AR, with the optimal administration interval is 60 minutes for PTM cells and Sertoli cells in Wistar rats testis.
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