ArticleOpen veterinary journal2024
Study of the effect of different diluents for syringe immersion test on
Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Macrocyclic lactones (MLs) are pharmaceutical compounds extensively utilized in the management of Aim: Study the interchangeability of two diluents in the diagnosis of sensitivity to MLs on Methods: Dose-response curves were adjusted using SIT with MLs, on different diluents [acetone (ACT) and dimethyl sulfoxide (DMSO)] on Mozo strain (standard susceptible strain). Slope, potency, and discriminating concentration were estimated for each drug on both diluents. A four-parameter log-logistic model was applied for model fitting. The ratio between estimated parameters was used to compare results. Field strains were tested on both diluents for each drug, using the discriminating concentration estimated for Mozo strain. Results: For the Mozo strain, dose-response models were adjusted for each drug on both diluents using SIT. Ivermectin (IVM) and doramectin (DRM) showed no significant difference in slope when comparing diluents ( Conclusion: We conclude that the SIT technique is a tool capable of detecting susceptibility/resistance in
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