ArticleOpen veterinary journal2024
Evaluation of the anti-diabetic and anti-inflammatory potentials of curcumin nanoparticle in diabetic rat induced by streptozotocin.
Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Beyond the Rhizome: Phytochemistry, Biological Activities, and Sustainable Utilization ofPharmaceuticals (Basel, Switzerland) · 2026Review
- Kaempferol conjugated selenium nanoparticles mitigate kidney injury from rhabdomyolysis through antioxidant and anti-inflammatory actions via Nrf2/NF-κb pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil-induced cardiotoxicity using kaempferol-mediated selenium nanoparticles.Scientific reports · 2026Article
- Naringenin protects against L-NAME-induced preeclampsia and fetal developmental abnormalities via modulation of inflammation, eNOS/NO signaling, AKT/mTOR pathway, and restoring endothelial function.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Rutin-Functionalized Selenium Nanoparticles Attenuate Cisplatin-Induced Cardiohepatic Injury in Rats: Modulation of ER Stress-Related Gene Expression and Mitochondrial Apoptotic Markers.International journal of molecular sciences · 2026Article
- Article
- Mechanistic Insights into Systemic Targets of Magnolia Mediating Beneficial Effects in Metabolic Syndrome through Biochemical and In Situ Analyses.Biochemical genetics · 2026Article
- Nephroprotective Effects of Quercetin-Selenium Nanoparticles Against Glycerol-Induced AKI.International journal of molecular sciences · 2025Article
- Decoding the effect of Diceratella elliptica on the oxidative stress-Inflammation axis in hyperthyroid-induced hepatotoxicity.Journal, genetic engineering & biotechnology · 2025Article
- Targeting Oxidative Stress and Neuroinflammation: Epigallocatechin-3-gallate-Selenium Nanoparticles Mitigate Sleep Deprivation-Induced Cortical Impairment.International journal of molecular sciences · 2025Article
- The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies.Frontiers in pharmacology · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Natural materials are frequently good options for drug development, regardless of their source. It has been demonstrated that curcumin boosts antioxidant capacity and guards against diabetic disorders. Aim: The current study aimed to evaluate the possible anti-inflammatory and anti-diabetic effects of curcumin-NPs (Cur-NPs) in streptozotocin-induced diabetic rats. Methods: Four groups of rats were randomly selected; (1) standard control group, (2) Cur-NPs group was given the regular food of rats along with 5 mg/kg of Cur-NPs daily, (3) Diabetic rats in the STZ group served as the positive control, and (4) Included in the STZ~Cur-NPs group were diabetic rats receiving Cur-NPs (5 mg/kg/day). Results: After receiving Cur-NPs treatment for 6 weeks, the levels of glucose, tumor necrosis factor alpha TNF-alpha, interlukin1 β (IL1β), interlukin-4, interlukin-6, interlukin-10, MDA, and NO in the diabetic animals were significantly reduced. Simultaneously, the levels of insulin, CAT, GPx, GSH, and SOD were significantly increased, approaching the levels of the corresponding healthy animals. Similarly, insulin secretion increased in the islet β-cells as shown by immunohistochemical analysis, indicating improved glycaemic control and eventual glucose commitment to glycolysis; its processes for scavenging free radicals and acting as an antioxidant may explain this behavior. Conclusion: As a result, our findings aid in the potential characterization and creation of novel therapeutic agents that prevent diabetes.
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