Evidence map›Paper›PMID 39927273›Full record

ArticleFrontiers in medicine2024

Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients.

Suxian Zhao, Chen Dong, Chudi Chang, Jiaming Zhang, Jing Li, Xiaoxiao Zhang, Weiguang Ren, Ying Zhang, Yuemin Nan

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PubMed Full text at PMC Publisher
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Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suxian ZhaoDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Chen DongDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Chudi ChangDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Jiaming ZhangDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Jing LiDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Xiaoxiao ZhangDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Weiguang RenDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Ying ZhangDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.
Yuemin NanDepartment of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base - Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: This research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients. Methods: From August 2013 to June 2022, CHB patients at Hebei Medical University Third Hospital (Hebei, China) were recruited. Intrahepatic cccDNA was quantified and its association with liver inflammation was analyzed. Liver inflammation was assessed using the Ishak-modified histological activity index (HAI). Biochemical and viral indicators as well as hepatic inflammation biomarkers were monitored. Results: In total, 55 CHB patients were enrolled. The average HBV-cccDNA level was markedly elevated in HBeAg+ patients compared to HBeAg patients. Intrahepatic cccDNA levels differed significantly in different liver inflammation groups and showed a positive correlation with the HAI score for hepatic inflammation. Conclusion: HBV-cccDNA level was associated with liver inflammation.

Indexed as

chronic hepatitis Bcovalently closed circular DNA (cccDNA)HBVinflammationliver

Identifiers

PMID39927273
PMCPMC11802545

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.