ArticleNanophotonics (Berlin, Germany)2025
Label-free (fluorescence-free) sensing of a single DNA molecule on DNA origami using a plasmon-enhanced WGM sensor.
Article in Nanophotonics (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Single-Molecule Detection Concepts Enabled by DNA Origami.Micromachines · 2026Review
- Direct Nanoparticle Sensing in Liquids with Free-Space Excited Optical Whispering-Gallery-Mode Microresonators.Sensors (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of DNA origami structures with opto-plasmonic whispering gallery mode (WGM) sensors offers a significant advancement in label-free biosensing, overcoming the limitations of traditional fluorescence-based techniques, and providing enhanced sensitivity and specificity for detecting DNA hybridization events. In this study, DNA origami acts as a scaffold for the precise assembly of plasmonic dimers, composed of gold nanorods (AuNRs), which amplify detection sensitivity by generating strong near-field enhancements in the nanogap between the nanorods. By leveraging the strong electromagnetic fields generated within the nanogap of the plasmonic dimer, this platform enables the detection of transient hybridization events between DNA docking strands and freely diffusing complementary sequences. Our findings demonstrate that the salt concentration critically influences DNA hybridization kinetics. Higher ionic strengths reduce electrostatic repulsion between negatively charged DNA strands, thereby stabilizing duplex formation and prolonging interaction times. These effects are most pronounced at salt concentrations around 300-500 mM, where optimal conditions for duplex stability and reduced dissociation rates are achieved. By thoroughly investigating the hybridization kinetics under varying environmental conditions, this study contributes to a deeper understanding of DNA interactions and offers a robust tool for single-molecule detection with real-time capabilities.
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Registered trials
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