ArticleJournal of diabetes and metabolic disorders2025
Exploring the causal relationship between GLP-1R agonists and diseases related to the thyroid and parathyroid: a mendelian randomization study.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Parathyroid carcinoma co-occurring with parathyroid adenoma and papillary thyroid carcinoma: a rare case report with comprehensive literature review.Therapeutic advances in endocrinology and metabolism · 2026Article
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Authors and funding
3 authors.
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Abstract
Glucagon-like peptide-1 receptor (GLP-1R) agonists are well-known for their benefits in managing obesity and diabetes. However, some studies indicate that they may elevate the risk of thyroid cancer. This study employed summary data-based Mendelian randomization (SMR) analysis, incorporating genetic data from GTEx V.8 and the UK Biobank, to assess how increased GLP-1R gene expression in thyroid and parathyroid tissues affects their functions. We found that increased expression of GLP-1R is a risk factor for hyperparathyroidism, but no causal relationship was found with thyroid dysfunction. Furthermore, we advise routine assessments of parathyroid function and hormone levels for patients on GLP-1R agonists. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01567-y.
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