Evidence map›Paper›PMID 39927121›Full record

ArticleArthroplasty today2025

Validation of a Novel Landmark-guided Intra-articular Postero-medial Surgeon-administered Injection Technique.

Nicolas S Piuzzi, Andrew I Spitzer, Jason Mussell, Ignacio Pasqualini, Stan Dysart, Jeffrey Gonzales, Michael A Mont, Jess H Lonner, William Mihalko

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroplasty today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06946368 narecruitingnot on this map

A Single-Center, Randomized, Pilot Study to Assess the Clinical Effectiveness of EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

TypeinterventionalSponsorThe Cleveland ClinicRan2025 to 2026Enrolled60ConditionsTotal Knee ArthroplastyArmsIntra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
NCT07584915 phase4enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

A Prospective, Single-Center, Randomized, Pilot Study to Assess the Clinical Effectiveness of EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block Compared to Local Infiltration Analgesia in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

TypeinterventionalSponsorCedars-Sinai Medical CenterRan2026 to 2026Enrolled40ConditionsTotal Knee Arthroplasty, Total Knee Arthroplasty RecoveryArmsIntra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicolas S PiuzziDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Andrew I SpitzerDepartment of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jason MussellDepartment of Orthopaedic Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Ignacio PasqualiniDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Stan DysartPacira BioSciences, Inc., Tampa, FL, USA.
Jeffrey GonzalesPacira BioSciences, Inc., Tampa, FL, USA.
Michael A MontDepartment of Orthopaedic Surgery, Sinai Hospital of Baltimore, Baltimore, MD, USA.
Jess H LonnerRothman Orthopaedics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
William MihalkoUniversity of Tennessee Health Science Center, Campbell Clinic Department of Orthopaedic Surgery, Memphis, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to define an intra-articular surgeon-administered technique that may be comparable to ultrasound (US)-guided adductor canal block (ACB). Methods: Five cadaver lower limbs were examined. An anesthesiologist administered a US-guided ACB using 20 mL of dilute indocyanine dye. An orthopedic surgeon performed a medial parapatellar arthrotomy and introduced an 18-gauge needle 1-2 cm proximal to the palpated adductor tubercle angled posteromedially. Needle position and dye spread were fluoroscopically documented. Results: This technique consistently reached the infrapatellar branch of the saphenous nerve, nerve to the vastus medialis muscle, and posterior capsule, with minimal proximal dye spread. Conclusions: This technique may be an efficient complement to ACB or surgeon infiltration or an alternative to US-guided ACB when it is not available.

Indexed as

AnesthesiaArthroplastyKneePainTotal knee arthroplasty

Identifiers

PMID39927121
PMCPMC11803215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.