Evidence map›Paper›PMID 39926995›Full record

ArticleJournal of pharmacy & bioallied sciences2024

Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion.

Rashmi P Yadahalli, Yazeed Abdullah Alotaibi, Ravinder Singh, Mohammed Najmuddin, Mohamed Tharwat Salama, Radha Prasanna Dalai, Noura Alessa, Vardarajula Venkat Ramaiah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacy & bioallied sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rashmi P YadahalliDepartment of Conservative Dentistry and Endodontics, PMNM Dental College and Hospital, Bagalkote, Karnataka, India.
Yazeed Abdullah AlotaibiGeneral Dentist, Qassim University, Saudi Arabia.
Ravinder SinghDepartment of Oral Medicine and Radiology, MMCDSR, Mullana, Ambala Cantt, Haryana, India.
Mohammed NajmuddinDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, KSA, Saudi Arabia.
Mohamed Tharwat SalamaSenior Lecturer in Paediatric Dentistry, Orthodontics and Paediatric Dentistry Department, Qassim University, Saudi Arabia.
Radha Prasanna DalaiDepartment of Public Health Dentistry, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be) University, Bubhaneswar, Odisha, India.
Noura AlessaDepartment of Paediatric Dentistry and Orthodontics, Dental College, King Saud University, Riyadh, Saudi Arabia.
Vardarajula Venkat RamaiahDepartment of Dental Hygiene, College of Applied Health Sciences, Ar Rass Qassim University, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Evaluation of effectiveness of bioactive glass, self-assembling peptide (P11-4), and arginine bicarbonate remineralizing agents on simulated carious lesion. Material and Methods: This research was conducted using 40 human premolar teeth that had just been removed. Remineralization of demineralized teeth was carried out three times a day for 14 days for 5 minutes using the appropriate remineralizing agents (Group A: calcium sodium phosphosilicate (bioactive glass), Group B: self-assembling peptide (P11-4), Group C: arginine bicarbonate remineralizing agents, and control group: Group D: deionized water). Using the Vickers hardness number, the degree of demineralization and remineralization was assessed. Results: In every group, there was a drop in microhardness from the baseline to demineralization. In all three test groups, the shift in microhardness values from demineralization to remineralization was shown to be statistically significant. Conclusion: Higher remineralizing capacity was found in bioactive glass and self-assembling peptide (P11-4), which can be employed therapeutically to treat early carious lesions.

Indexed as

Arginine bicarbonatebioactive glassdental cariesremineralizationself-assembling peptide (P11-4)

Identifiers

PMID39926995
PMCPMC11805044

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.