ArticleJournal of pharmacy & bioallied sciences2024
Efficacy of Next-Generation Sequencing in Identifying Genetic Markers for Prostate Cancer Risk.
Article in Journal of pharmacy & bioallied sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Prostate cancer is one of the most prevalent cancers among men worldwide. The identification of genetic markers that contribute to the risk of prostate cancer can significantly enhance early diagnosis and personalized treatment strategies. Next-Generation Sequencing (NGS) has emerged as a powerful tool for uncovering genetic variations associated with various cancers, including prostate cancer. Materials and Methods: A cohort of 200 men, consisting 100 diagnosed with prostate cancer and 100 healthy controls, was recruited for this study. DNA samples were extracted from blood and tumor tissues, followed by library preparation and sequencing using an Illumina platform. Bioinformatic analysis was conducted to identify single nucleotide polymorphisms (SNPs), copy number variations (CNVs), and other genetic alterations linked to prostate cancer. Statistical analysis was performed to assess the association between identified genetic markers and prostate cancer risk. Results: NGS identified a total of 450 genetic variants, with 50 SNPs showing a strong association with prostate cancer risk ( Conclusion: This study demonstrates the efficacy of NGS in identifying genetic markers associated with prostate cancer risk.
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