ArticleJournal of pharmacy & bioallied sciences2024
The Neonatal Screening for Sickle Cell Disease, Thalassemia, and G6PD Deficiency in Central India.
Article in Journal of pharmacy & bioallied sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Birth Prevalence of Sickle Cell Disease in India: A Systematic Review and Meta-Analysis.International journal of neonatal screening · 2026Review
- Review
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Authors and funding
5 authors.
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Abstract
Background: Sickle cell disease (SCD), thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency are significant genetic disorders prevalent in Central India, particularly among tribal populations. Early detection through the neonatal screening can improve health outcomes. Aim and Objective: This study aims to assess the prevalence of SCD, thalassemia, and G6PD deficiency in a cohort of newborns from tribal regions in Central India and to evaluate the effectiveness of neonatal screening programs. Materials and Methods: A total of 382 newborns were screened using high-performance liquid chromatography (HPLC) for hemoglobinopathies and a colorimetric method for G6PD deficiency. Data on demographics and family history were collected and analyzed. Results: The screening revealed 22 cases of SCD (5.8%), 37 cases of thalassemia (9.7%), and 29 cases of G6PD deficiency (7.6%). A significant correlation was found between family history and the prevalence of these disorders. Conclusion: The findings highlight the need for comprehensive neonatal screening programs in tribal populations to enhance early detection and management of genetic disorders.
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