Evidence map›Paper›PMID 39926615›Full record

ArticleBrain communications2025

The inflammatory APRIL (a proliferation-inducing ligand) antagonizes chondroitin sulphate proteoglycans to promote axonal growth and myelination.

Mashal Claude Ahmed, Tejaswini Kakunuri, Leticia Peris, Delphine Meffre, Elif Nur Yilmaz, Laureen Grewing, Raquel Guerrero González, Benoit Manfroi, Evelyne Gout, Romain R Vivès and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mashal Claude AhmedInstitute for Advanced Biosciences, University Grenoble-Alpes/INSERM U1209/CNRS UMR5209, La Tronche 38700, France.
Tejaswini KakunuriT-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche 38700, France.
Leticia PerisInstitut des Neurosciences, Université Grenoble Alpes, La Tronche 38700, France.
Delphine MeffreUMR-S 1124, University Paris-Cité and INSERM, Paris 75006, France.
Elif Nur YilmazInstitute of Neuropathology, University Hospital Muenster, Muenster 8149, Germany.
Laureen GrewingInstitute of Neuropathology, University Hospital Muenster, Muenster 8149, Germany.
Raquel Guerrero GonzálezInstitute of Neuropathology, University Hospital Muenster, Muenster 8149, Germany.
Benoit ManfroiInstitute for Advanced Biosciences, University Grenoble-Alpes/INSERM U1209/CNRS UMR5209, La Tronche 38700, France.
Evelyne GoutCNRS, CEA, IBS, University of Grenoble Alpes, Grenoble 38000, France.
Romain R VivèsCNRS, CEA, IBS, University of Grenoble Alpes, Grenoble 38000, France.
Una FitzgeraldGalway Neuroscience Centre, School of Natural Sciences, National University of Ireland, Galway H91 W2TY, Ireland.
Pascal SchneiderDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.
Mehrnaz Jafarian-TehraniUMR-S 1124, University Paris-Cité and INSERM, Paris 75006, France.
Tanja KuhlmannInstitute of Neuropathology, University Hospital Muenster, Muenster 8149, Germany.
Bertrand HuardT-RAIG, TIMC, University Grenoble-Alpes/CNRS UMR5525, La Tronche 38700, France.ORCID https://orcid.org/0000-0003-1358-6576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lesions in the CNS are frequently associated to a detrimental inflammatory reaction. In autoimmune neurodegenerative diseases, a proliferation-inducing ligand (APRIL) produced by CNS-infiltrating inflammatory cells binds to chondroitin sulphate proteoglycans (CSPGs). The latter are well-established obstacles to neural regeneration and remyelination in the CNS by interacting with receptor protein tyrosine phosphatase (RPTP) and Nogo receptor (NgR) families. Here, we are showing that APRIL blocks the interactions of RPTP and NgR with all types of chondroitin sulphate (CS). Functionally, APRIL neutralized the inhibitory effects of CS on mouse and human neuronal process growth. APRIL also blocked the inhibition of CS on mouse and human oligodendrocyte differentiation. Finally, APRIL increased myelination in an

Indexed as

a proliferation-inducing ligandchondroitin sulphate proteoglycanCNSregeneration

Identifiers

PMID39926615
PMCPMC11803424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.