Evidence map›Paper›PMID 39926558›Full record

ArticleACS omega2025

Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from

Renan A Gomes, Marcelo D Polêto, Hugo Verli, Vitor M Almeida, Sandro R Marana, Andreas Bender, Bruna F Godoi, Vinícius T L Rodrigues, Flavio da S Emery, Gustavo H G Trossini

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renan A GomesDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenue. Lineu Prestes, 580, Cidade Universitária, São Paulo, São Paulo 05508-000, Brazil.
Marcelo D PolêtoCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenue Bento Gonçalves, 9500, Porto Alegre, Rio Grande do Sul 91500-970, Brazil.ORCID https://orcid.org/0000-0001-9210-690X
Hugo VerliCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenue Bento Gonçalves, 9500, Porto Alegre, Rio Grande do Sul 91500-970, Brazil.
Vitor M AlmeidaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Avenue Prof. Lineu Prestes, 748, São Paulo, São Paulo 05508-000, Brazil.
Sandro R MaranaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Avenue Prof. Lineu Prestes, 748, São Paulo, São Paulo 05508-000, Brazil.
Andreas BenderCentre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID https://orcid.org/0000-0002-6683-7546
Bruna F GodoiCentre for Research and Advancement in Fragments and Molecular Targets (CRAFT), Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Prof. Zeferino Vaz, Campus USP, Ribeirão Preto, São Paulo 14040-903, Brazil.
Vinícius T L RodriguesCentre for Research and Advancement in Fragments and Molecular Targets (CRAFT), Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Prof. Zeferino Vaz, Campus USP, Ribeirão Preto, São Paulo 14040-903, Brazil.
Flavio da S EmeryCentre for Research and Advancement in Fragments and Molecular Targets (CRAFT), Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Prof. Zeferino Vaz, Campus USP, Ribeirão Preto, São Paulo 14040-903, Brazil.ORCID https://orcid.org/0000-0002-8652-7123
Gustavo H G TrossiniDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenue. Lineu Prestes, 580, Cidade Universitária, São Paulo, São Paulo 05508-000, Brazil.ORCID https://orcid.org/0000-0003-3634-2531

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sirtuin-2 (Sir2) is a histone deacetylase recognized as an antitrypanosomal target, yet there is limited knowledge regarding their potent inhibitors. This investigation employs the fragment-based drug discovery (FBDD) framework to identify novel inhibitors against

Identifiers

PMID39926558
PMCPMC11799985

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.