ArticleMolecular and clinical oncology2025
Giant dedifferentiated liposarcoma of the neck with osteosarcoma and chondrosarcoma components: A case report.
Article in Molecular and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dedifferentiated liposarcoma (DDLPS) is a subtype of LPS characterized by two distinct levels of differentiation and morphological structures, comprising areas of well-differentiated LPS and dedifferentiated, non-lipogenic, highly malignant components. DDLPS most frequently occurs in the retroperitoneum and the soft tissues of the pelvis and limbs, and is rare in the head and neck region, accounting for only 1% of head and neck sarcomas. The present study describes the case of a 72-year-old male with a 30-year history of left upper limb numbness and heaviness. During physical examination, a tumor measuring ~13x22 cm was discovered in the left posterior region of the head and neck. The mass was hard in texture and had limited mobility. A biopsy of the lesion revealed a mesenchymal tumor rich in adipose components with ossification, containing heterologous elements primarily indicative of osteosarcoma, highly suggestive of DDLPS. A radical excision of the tumor was subsequently performed. The surgical specimen exhibits cross-sections with a gray-white to gray-yellow solid consistency, featuring gray-white, semi-transparent areas resembling cartilage. Immunohistochemical staining was positive for murine double minute 2 (MDM2), cyclin-dependent kinase 4 (CDK4), P16, P53, Vimentin and Ki-67, and negative for cytokeratin pan, S-100, CD34 and smooth muscle actin. Fluorescence
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