ArticleMolecular therapy. Nucleic acids2025
lncRNA localization and feature interpretability analysis.
Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Functional characterization of lncIMF_17214 in regulating intramuscular fat deposition of yellow-feathered broilers.Poultry science · 2026Article
- AWTI-Net Enables Accurate and Interpretable Functional Assessment of Disease-Associated LncRNA Mutations.Interdisciplinary sciences, computational life sciences · 2026Article
- Article
- Reference-guided genome assembly of long non-coding rna transcripts reveals target genes associated with Crohn's disease.Scientific reports · 2026Article
- LINC02178 drives lung adenocarcinoma progression and serves as a therapeutic target for nanodelivery-based intervention.Scientific reports · 2025Article
- From nucleotides to numbers: a comprehensive review of RNA feature extraction methods for computational modelling.Briefings in bioinformatics · 2025Review
- Unlocking RNA mysteries: Predicting subcellular localizations with AI.Molecular therapy. Nucleic acids · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcellular localization is crucial for understanding the functions and regulatory mechanisms of biomolecules. Long non-coding RNAs (lncRNAs) have diverse roles in cellular processes, and their localization within specific subcellular compartments provides insights into their biological functions and implications in health and disease. The nucleolus and nucleoplasm are key hubs for RNA metabolism and cellular regulation. We developed a model, LncDNN, for identifying the localization of lncRNAs in the nucleolus and nucleoplasm. LncDNN uses three different encoding schemes and employs Shapley Additive Explanations for feature analysis and selection. The results show that LncDNN is more accurate than other models. Additionally, an interpretable analysis of the features influencing the model was conducted. LncDNN is applicable for identifying the localization of lncRNA in the nucleolus and nucleoplasm, aiding in the understanding and in-depth study of related biological processes and functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.