ArticleWorld journal of gastroenterology2025
Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multiparametric MRI-based multi-channel deep learning model for accurate preoperative prediction of perineural invasion in lymph node-negative rectal cancer.Abdominal radiology (New York) · 2026Article
- Risk factors for residual cancer and lymph node metastasis after non-curative endoscopic resection of colorectal cancer: a multicenter retrospective study.BMC gastroenterology · 2026Article
- The value of extracellular volume based on spectral CT in lymph node metastasis, perineural invasion, and lymphovascular invasion of colon cancer.Abdominal radiology (New York) · 2026Article
- Prediction of lymphovascular invasion in rectal cancer based on multimodal magnetic resonance imaging radiomics model.World journal of gastrointestinal surgery · 2026Article
- Spectral CT imaging in colorectal cancer: current applications, limitations, and future perspectives.Insights into imaging · 2026Review
- Predicting lymph node metastasis in colorectal cancer using case-level multiple instance learning.World journal of gastroenterology · 2026Article
- Association between the histopathologic measurement of tumor-visceral peritoneal distance and prognosis in T3 colon adenocarcinoma.Pathology oncology research : POR · 2026Article
- Integrating lymphovascular and perineural invasion into TNM staging: a novel ITNM system for enhanced prognostic stratification in colorectal cancer.Frontiers in oncology · 2026Article
- Integrative multi-region MRI radiomics and clinical nomogram for preoperative lymphovascular invasion prediction in rectal cancer: a multicenter validation.BMC medical imaging · 2025Article
- Machine Learning-Based Pathomics Signature for Perineural Invasion in Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Important role of tumor deposits and negative lymph nodes in prognosis of N1c colorectal cancer patients.World journal of gastroenterology · 2025Article
- Impact of emergency presentation on early surgical and oncological outcomes in rectosigmoid cancer: a single-center retrospective analysis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Comparative overall survival in T4N0 and T2-3N1 non-metastatic colon cancer: a retrospective cohort study.Annals of Saudi medicineArticle
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13 authors.
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Abstract
backgroundLymphovascular invasion (LVI) and perineural invasion (PNI) are associated with decreased survival in colorectal cancer (CRC), but its significance in N1c stage remains to be clearly defined.
aimTo evaluate LVI and PNI as potential prognostic indicators in N1c CRC.
methodsWe retrospectively identified 107 consecutive patients who had CRC with N1c disease radically resected at our hospital. Tumors were reviewed for LVI and PNI by one pathologist blinded to the patients' outcomes. Disease-free survival (DFS), overall survival (OS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method, with LVI and PNI prognosis differences determined by multivariate analysis using the Cox multiple hazards model. Results were compared using log-rank test. The receiver operating characteristic (ROC) curve was used to evaluate the prognostic predictive ability.
resultsThe median follow-up time was 63.17 (45.33-81.37) months for DFS, with 33.64% (36/107) of patients experiencing recurrence; 21.5% of tumors were found to be LVI positive and 44.9% PNI positive. The 5-year DFS rate was greater for patients with LVI-negative tumors compared with LVI-positive tumors (74.0%
conclusionLVI and PNI could serve as independent prognostic factors of outcomes in N1c CRC patients. Patients with LVI or PNI should be given more attention during treatment.
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